MIF Antagonist, ISO-1
- Product Name
- MIF Antagonist, ISO-1
- CAS No.
- 478336-92-4
- Chemical Name
- MIF Antagonist, ISO-1
- Synonyms
- ISO-1;CS-1195;ISO-1 (ISO 1;MIF Antagonist;ISO-1, MIF Antagonist;MIF Antagonist, ISO-1;ISO 1;ISO1;MIF ANTAGONIST;ISO-1,Inhibitor,ISO1,inhibit;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester
- CBNumber
- CB62521242
- Molecular Formula
- C12H13NO4
- Formula Weight
- 235.24
- MOL File
- 478336-92-4.mol
MIF Antagonist, ISO-1 Property
- Melting point:
- 114 °C
- Boiling point:
- 365.0±48.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO.
- pka
- 9.22±0.30(Predicted)
- form
- Light yellow crystalline solid.
- color
- Off-white
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 5.05225
- Product name
- InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- Packaging
- 10MG
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 475837
- Product name
- MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- Purity
- The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
- Packaging
- 5MG
- Price
- $144
- Updated
- 2024/03/01
- Product number
- I1119
- Product name
- ISO-1
- Packaging
- 5MG
- Price
- $85
- Updated
- 2024/03/01
- Product number
- I1119
- Product name
- ISO-1
- Packaging
- 25MG
- Price
- $254
- Updated
- 2024/03/01
- Product number
- J64947
- Product name
- MIF Antagonist, ISO-1
- Packaging
- 5mg
- Price
- $114
- Updated
- 2023/06/20
MIF Antagonist, ISO-1 Chemical Properties,Usage,Production
Description
ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis.1 Inhibits airway remodeling in mouse asthma model.2 ISO-1 also blocks MIF-induced autophagy.3?Active in cellular and mouse models.
Uses
MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
storage
Store at +4°C
References
1) Al-Abed et al. (2005), ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis; J. Biol. Chem., 280 2) Chen et al. (2010), ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma; Mol. Med., 16 400 3) Chuang et al. (2012), Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation; PLoS One, 7 e37613
MIF Antagonist, ISO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MIF Antagonist, ISO-1 Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from MIF Antagonist, ISO-1 manufacturers
- Product
- MIF Antagonist, ISO-1 478336-92-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22