ChemicalBook > CAS DataBase List > NSC697923

NSC697923

Product Name: NSC697923
CAS No.: 343351-67-7
Chemical Name: NSC697923
Synonyms: NSC697923;NSC697923 USP/EP/BP;2-Nitro-5-tosylfuran;NSC697923, 10 mM in DMSO;NSC697923, UBE2N inhibitor;UbcH13 Inhibitor, NSC697923;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
CBNumber: CB62666859
Molecular Formula: C11H9NO5S
Formula Weight: 267.25786
MOL File: 343351-67-7.mol

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NSC697923 Property

Melting point:: 124-126°C
Boiling point:: 443.8±40.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0618
Product name: NSC697923
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $47.81
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0618
Product name: NSC697923
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $239
Updated: 2025/07/31

Sigma-Aldrich

Product number: 662107
Product name: UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem
Purity: The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging: 25MG
Price: $226
Updated: 2025/07/31

Cayman Chemical

Product number: 15346
Product name: NSC 697923
Purity: ≥98%
Packaging: 1mg
Price: $23
Updated: 2024/03/01

Cayman Chemical

Product number: 15346
Product name: NSC 697923
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

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NSC697923 Chemical Properties,Usage,Production

Description

NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4

Uses

NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).

in vivo

NSC697923 (5?mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts^[1].

Animal Model:	5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts)^[1]
Dosage:	5?mg/kg
Administration:	I.p.; daily for 10 days
Result:	Significant tumor regression in both SH-SY5Y and NGP xenografts.

storage

+4°C

References

[1] MARY PULVINO. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.[J]. Blood, 2012, 120 8: 1668-1677. DOI:10.1182/blood-2012-02-406074
[2] SAM STRICKSON. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.[J]. Biochemical Journal, 2013, 451 3: 427-437. DOI:10.1042/bj20121651
[3] CURTIS D. HODGE. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting[J]. ACS Chemical Biology, 2015, 10 7: 1718-1728. DOI:10.1021/acschembio.5b00222
[4] J CHENG. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways[J]. Cell Death & Disease, 2014, 5 2: e1079-e1079. DOI:10.1038/cddis.2014.54

NSC697923 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC697923 Suppliers

China 90 India 1 United Kingdom 2 United States 14 Global 107

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343351-67-7, NSC697923Related Search:

Motesanib YM155 (Sepantronium Bromide) Bortezomib PYR 41 Nutlin-3 Deltarasin 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE NSC 23766 TETRAHYDROCHLORIDE MIF Antagonist, ISO-1 GSK-3β Inhibitor XVIII Pictilisib JNJ-10198409 NSC23005 Sodium NSC632839hydrochloride KENPAULLONE NSC5844 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-

NSC697923

2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran

2-Nitro-5-tosylfuran

2-Nitro-5-(toluene-4-sulfonyl)-furan

2-[(4-Methylphenyl)sulfonyl]-5-nitrofur

NSC697923 USP/EP/BP

NSC697923, UBE2N inhibitor

NSC697923, 10 mM in DMSO

UbcH13 Inhibitor, NSC697923

343351-67-7

Inhibitors