NSC697923
- Product Name
- NSC697923
- CAS No.
- 343351-67-7
- Chemical Name
- NSC697923
- Synonyms
- NSC697923;NSC697923 USP/EP/BP;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
- CBNumber
- CB62666859
- Molecular Formula
- C11H9NO5S
- Formula Weight
- 267.25786
- MOL File
- 343351-67-7.mol
NSC697923 Property
- Melting point:
- 124-126°C
- Boiling point:
- 443.8±40.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0618
- Product name
- NSC697923
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $46.86
- Updated
- 2024/03/01
- Product number
- SML0618
- Product name
- NSC697923
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $273
- Updated
- 2024/03/01
- Product number
- 662107
- Product name
- UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem
- Purity
- The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging
- 25MG
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 15346
- Product name
- NSC 697923
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $23
- Updated
- 2024/03/01
- Product number
- 15346
- Product name
- NSC 697923
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
NSC697923 Chemical Properties,Usage,Production
Description
NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
Uses
NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
storage
+4°C
References
1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079