ChemicalBook > CAS DataBase List > NSC697923

NSC697923

Product Name
NSC697923
CAS No.
343351-67-7
Chemical Name
NSC697923
Synonyms
NSC697923;NSC697923 USP/EP/BP;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
CBNumber
CB62666859
Molecular Formula
C11H9NO5S
Formula Weight
267.25786
MOL File
343351-67-7.mol
More
Less

NSC697923 Property

Melting point:
124-126°C
Boiling point:
443.8±40.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0618
Product name
NSC697923
Purity
≥98% (HPLC)
Packaging
5mg
Price
$46.86
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0618
Product name
NSC697923
Purity
≥98% (HPLC)
Packaging
25mg
Price
$273
Updated
2024/03/01
Sigma-Aldrich
Product number
662107
Product name
UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem
Purity
The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
25MG
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
15346
Product name
NSC 697923
Purity
≥98%
Packaging
1mg
Price
$23
Updated
2024/03/01
Cayman Chemical
Product number
15346
Product name
NSC 697923
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
More
Less

NSC697923 Chemical Properties,Usage,Production

Description

NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4

Uses

NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).

storage

+4°C

References

1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079

NSC697923 Preparation Products And Raw materials

Raw materials

Preparation Products

343351-67-7, NSC697923Related Search:


  • Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
  • NSC697923
  • 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
  • 2-Nitro-5-tosylfuran
  • 2-Nitro-5-(toluene-4-sulfonyl)-furan
  • 2-[(4-Methylphenyl)sulfonyl]-5-nitrofur
  • NSC697923 USP/EP/BP
  • 343351-67-7
  • Inhibitors