3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
- Product Name
- 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
- CAS No.
- 7497-07-6
- Chemical Name
- 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
- Synonyms
- CS-1114;NSC 405020;NSC 405020, >=98%;NSC 405020;NSC-405020;NSC 405020, 7497-07-6;NSC405020, 98%, MT1-MMP inhibitor;3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE;3,4-Dichloro-N-(1-Methylbutyl)benza-Mide;Benzamide, 3,4-dichloro-N-(1-methylbutyl)-;3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020
- CBNumber
- CB82658339
- Molecular Formula
- C12H15Cl2NO
- Formula Weight
- 260.16
- MOL File
- 7497-07-6.mol
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Property
- Boiling point:
- 353.7±32.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
- form
- powder
- pka
- 13.38±0.46(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0518
- Product name
- NSC405020
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- SML0518
- Product name
- NSC405020
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $386
- Updated
- 2024/03/01
- Product number
- 14859
- Product name
- NSC 405020
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14859
- Product name
- NSC 405020
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 14859
- Product name
- NSC 405020
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties,Usage,Production
Description
NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3
Uses
NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.
storage
Store at RT
References
1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide manufacturers
- Product
- NSC 405020 7497-07-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30