3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

ChemicalBook > CAS DataBase List > 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Product Name: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
CAS No.: 7497-07-6
Chemical Name: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
Synonyms: CS-1114;NSC 405020;NSC 405020, >=98%;NSC 405020;NSC-405020;NSC 405020, 7497-07-6;NSC405020, 98%, MT1-MMP inhibitor;3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE;3,4-Dichloro-N-(1-Methylbutyl)benza-Mide;Benzamide, 3,4-dichloro-N-(1-methylbutyl)-;3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020
CBNumber: CB82658339
Molecular Formula: C12H15Cl2NO
Formula Weight: 260.16
MOL File: 7497-07-6.mol

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3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Property

Boiling point:: 353.7±32.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form: powder
pka: 13.38±0.46(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26-24/25
RIDADR: 3077
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0518
Product name: NSC405020
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0518
Product name: NSC405020
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2024/03/01

Cayman Chemical

Product number: 14859
Product name: NSC 405020
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14859
Product name: NSC 405020
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 14859
Product name: NSC 405020
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

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3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties,Usage,Production

Description

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3

Uses

NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.

storage

Store at RT

References

1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide manufacturers

Career Henan Chemical Co

Product: NSC 405020 7497-07-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

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3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

NSC 405020

3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE

3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020

NSC 405020 3,4-Dichloro-N-(1-methylbutyl)-benzamide

NSC 405020, >=98%

NSC 405020, 7497-07-6

NSC 405020;NSC-405020

NSC405020, 98%, MT1-MMP inhibitor

CS-1114

Benzamide, 3,4-dichloro-N-(1-methylbutyl)-

7497-07-6

7497-07-7

7494-07-6

Inhibitors