ChemicalBook > CAS DataBase List > 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide

Product Name
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
CAS No.
7497-07-6
Chemical Name
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
Synonyms
CS-1114;NSC 405020;NSC 405020, >=98%;NSC 405020 ，S8072;NSC 405020;NSC-405020;NSC 405020, 7497-07-6;MT1-MMP Inhibitor, NSC405020;NSC405020, 98%, MT1-MMP inhibitor;3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE;3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
CBNumber
CB82658339
Molecular Formula
C12H15Cl2NO
Formula Weight
260.16
MOL File
7497-07-6.mol
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3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Property

Boiling point:
353.7±32.0 °C(Predicted)
Density 
1.182±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form 
powder
pka
13.38±0.46(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-24/25
RIDADR 
3077
WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0518
Product name
NSC405020
Purity
≥98% (HPLC)
Packaging
5mg
Price
$126
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0518
Product name
NSC405020
Purity
≥98% (HPLC)
Packaging
25mg
Price
$337
Updated
2025/07/31
Cayman Chemical
Product number
14859
Product name
NSC 405020
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14859
Product name
NSC 405020
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
14859
Product name
NSC 405020
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
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3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties,Usage,Production

Description

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3

Uses

NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.

storage

Store at RT

References

[1] ALBERT G REMACLE. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.[J]. Cancer research, 2012: 2339-2349. DOI:10.1158/0008-5472.can-11-4149
[2] MIZUHO KITTAKA. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts[J]. Journal of Bone and Mineral Research, 2017, 33 1: 167-181. DOI:10.1002/jbmr.3295
[3] NGUYEN DINH THANG. Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma.[J]. PLoS ONE, 2014: e96945. DOI:10.1371/journal.pone.0096945

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide manufacturers

Career Henan Chemical Co
Product
NSC 405020 7497-07-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

7497-07-6, 3,4-Dichloro-N-(1-Methylbutyl)benza-MideRelated Search:

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  • 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
  • NSC 405020
  • 3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE
  • 3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020
  • NSC 405020 3,4-Dichloro-N-(1-methylbutyl)-benzamide
  • NSC 405020, >=98%
  • NSC 405020, 7497-07-6
  • NSC 405020;NSC-405020
  • NSC405020, 98%, MT1-MMP inhibitor
  • CS-1114
  • Benzamide, 3,4-dichloro-N-(1-methylbutyl)-
  • MT1-MMP Inhibitor, NSC405020
  • NSC 405020 ，S8072
  • 7497-07-6
  • 7497-07-7
  • 7494-07-6
  • Inhibitors