Deltarasin

Product Name: Deltarasin
CAS No.: 1440898-61-2
Chemical Name: Deltarasin
Synonyms: Deltarasin;deltarasine;Deltarasin-HCl;Deltarasin USP/EP/BP;Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras;(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole;2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole;1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-
CBNumber: CB22666619
Molecular Formula: C40H37N5O
Formula Weight: 603.75
MOL File: 1440898-61-2.mol

More

Less

Deltarasin Property

Boiling point:: 824.3±75.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 10.35±0.10(Predicted)
color: White
CAS DataBase Reference: 1440898-61-2

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 5424
Product name: Deltarasin
Purity: ≥99%(HPLC)
Packaging: 10
Price: $254
Updated: 2021/12/16

Usbiological

Product number: 446059
Product name: Deltarasin
Packaging: 2.5mg
Price: $425
Updated: 2021/12/16

Usbiological

Product number: 255122
Product name: Deltarasin
Packaging: 10mg
Price: $545
Updated: 2021/12/16

TRC

Product number: D231315
Product name: Deltarasin
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-1611
Product name: Deltarasin
Purity: 96.32%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

More

Less

Deltarasin Chemical Properties,Usage,Production

Uses

Deltarasin is an inhibitior of KRAS-PDEδ which has been shown to impair oncogenic signalling.

Biological Activity

the kras oncogene product is considered a major target in anticancer drug discovery. interfering with binding of mammalian pdeδ to kras by means of small molecules provides a novel opportunity to suppress oncogenic ras signalling by altering its localization to endomembranes. deltarasin is an inhibitor of the kras-pdeδ interaction to impair oncogenic kras signalling.

in vitro

within a minute, 5 mm of deltarasin completely inhibited pdeδ-kras interaction and released the insolubilized mcitrine-rheb/kras6q to the endomembrane system. this showed that deltarasin interfered with the binding of kras to pdeδ in cells and thereby inhibited its solubilization [1].

in vivo

a clear dose-dependent reduction in panc-tu-i tumour growth rate could be observed in deltarasin treated mice with respect to the vehicle-injected controls, where the growth of tumours in mice that were treated with 10mg kg/1 bid deltarasin was almost completely blocked [1].

References

[1] zimmermann g, papke b, ismail s, vartak n, chandra a, hoffmann m, hahn sa, triola g, wittinghofer a, bastiaens pi, waldmann h. small molecule inhibition of the kras-pdeδ interaction impairs oncogenic kras signalling. nature. 2013;497(7451):638-42.

Deltarasin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Deltarasin Suppliers

China 53 India 1 The Netherlands 1 United States 11 Global 66

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 18017383231 18017383231
Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
ProdList: 9347
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

DKMbiochem.Co. Ltd

Tel: 15901859516
Fax: 15901859516
Email: sales@DKMbiochem.com
Country: China
ProdList: 344
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4456
Advantage: 55

More

Less

View Lastest Price from Deltarasin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Deltarasin 1440898-61-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

Career Henan Chemical Co

Product: Deltarasin 1440898-61-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

1440898-61-2, DeltarasinRelated Search:

Selumetinib Axitinib NSC697923 AZD 5438 BAY 87-2243

Deltarasin

Deltarasin-HCl

2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole

1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-

deltarasine

Deltarasin USP/EP/BP

(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole

Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras

1440898-61-2

C40H37N5O

Inhibitors

API