Cefetamet hydrochloride
Synthesis- Product Name
- Cefetamet hydrochloride
- CAS No.
- 65052-63-3
- Chemical Name
- Cefetamet hydrochloride
- Synonyms
- Cefyl;LY-97964;FR-13300;Globocef;Ceftamet;LY-097964;CEFETAMET;Ro-15-8074;Ceftamet acid;CEFETAMET ACID
- CBNumber
- CB0266851
- Molecular Formula
- C14H15N5O5S2
- Formula Weight
- 397.43
- MOL File
- 65052-63-3.mol
Cefetamet hydrochloride Property
- Melting point:
- >178°C (dec.)
- Density
- 1.83±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- pka
- 3.11±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 65052-63-3(CAS DataBase Reference)
Safety
- HS Code
- 2941906000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C242770
- Product name
- Cefetamet
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 163031
- Product name
- Cefetamet
- Packaging
- 500mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- C242770
- Product name
- Cefetamet
- Packaging
- 5g
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- API0015818
- Product name
- (6R,7R)-7-[2-(2-AMINO-THIAZOL-4-YL)-2-METHOXYIMINO-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1106.03
- Updated
- 2021/12/16
- Product number
- H783
- Product name
- Cefetamet
- Packaging
- 250mg
- Price
- $297
- Updated
- 2021/12/16
Cefetamet hydrochloride Chemical Properties,Usage,Production
Synthesis
Suspend 2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetic acid in tetrahydrofuran, add half amount of phosphorus oxychloride dropwise at 0 °C, keep the temperature not more than 5 Chemicalbook °C, dropwise The reaction was completed for 30 minutes. Dimethylformamide and the other half of phosphorus oxychloride were added, and the reaction was carried out at 0 °C for 1 h to obtain a solution of active ester (I) at -5 °C.
7-ADCA, bis-trimethylsilyl urea and ethyl acetate were refluxed at 75-77 °C for 2 h to obtain a solution of 7-ADCA silicon ester, which was cooled to -5 °C. It was combined with the solution of active ester and stirred at -5～0°C Chemicalbook for 2h. Be raised to 15 ℃, add water, stir for 30min. Separate the water layer, adjust to Ph=2.6～3.0 with sodium hydroxide solution, place to separate out crystallization. Filtration, acetone recrystallization to give Cefetamet, yield 82%.
Description
Ceftazidime hydrochloride is an oral third-generation cephalosporin, which has the same antibacterial activity against gram-positive bacteria as cefixime, and is superior to cefaclor, especially against Streptococcus pneumoniae and Streptococcus pyogenes. It has obvious antibacterial activity against a variety of gram-negative bacteria such as Escherichia coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae, especially against Serratia, indole-positive Proteus, Enterobacter The antibacterial activity of Citrobacter and Citrobacter was significantly enhanced.
Uses
Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.
Definition
ChEBI: Cefetamet is a cephalosporin compound having methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups; a cephalosporin antibiotic active against Neisseria gonorrhoeae.
Antimicrobial activity
A semisynthetic cephalosporin formulated for oral use as the
prodrug ester, cefetamet pivoxyl. It is less active than cefaclor
and cefadroxil against Staph. aureus, but as active against
streptococci and more active against enterobacteria, H. influenzae
and N. gonorrhoeae, including β-lactamase-producing
strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk.
cepacia are all resistant. It is resistant to hydrolysis by common
plasmid-mediated enzymes.
The absolute bioavailability is about 50%. The plasma peak
is delayed by food. Binding to plasma protein is about 20%.
The volume of distribution approximates to the extracellular
water. It is excreted into urine with a half-life of 2–2.5 h,
principally in the glomerular filtrate. Elimination is linearly
related to creatinine clearance. Side effects and uses are similar
to those of other group 5 cephalosporins.
Cefetamet hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefetamet hydrochloride manufacturers
- Product
- Cefotaxime EP Impurity A 65052-63-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2024-12-19
- Product
- Cefetamet hydrochloride 65052-63-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Cefetamet hydrochloride 65052-63-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 300 MT
- Release date
- 2020-05-23