ChemicalBook > CAS DataBase List > AZD 9668

AZD 9668

Product Name: AZD 9668
CAS No.: 848141-11-7
Chemical Name: AZD 9668
Synonyms: AZD9668;CS-1060;AZD-9668;AZD 9668;MPH-966);Avelestat;Alvelestat;Cavosonstat;Alvelestat-13C,d3;Avelestat (AZD9668)
CBNumber: CB02668624
Molecular Formula: C25H22F3N5O4S
Formula Weight: 545.53
MOL File: 848141-11-7.mol

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AZD 9668 Property

Melting point:: 207-209°C
Boiling point:: 780.4±60.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.00±0.20(Predicted)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26083
Product name: AZD 9668
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 26083
Product name: AZD 9668
Packaging: 25mg
Price: $426
Updated: 2024/03/01

Cayman Chemical

Product number: 26083
Product name: AZD 9668
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 26083
Product name: AZD 9668
Packaging: 10mg
Price: $193
Updated: 2024/03/01

TRC

Product number: A794660
Product name: Avelestat
Packaging: 25mg
Price: $475
Updated: 2021/12/16

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AZD 9668 Chemical Properties,Usage,Production

Description

AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC₅₀ = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC₅₀s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.

Uses

Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.

in vivo

Alvelestat (1-10 mg/kg; oral administration; twice daily; for 4 days; Female BALB/cJBomTac mice) treatment reduces the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1β^[1].

Animal Model:	Female BALB/cJBomTac mice exposed to smoke cigarette smoke^[1]
Dosage:	1 mg/kg , 3 mg/kg , 6 mg/kg , 10 mg/kg
Administration:	Oral administration; twice daily; for 4 days
Result:	Reduced the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1β.

target

References

[1] stevens t, ekholm k, gränse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.

AZD 9668 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AZD 9668 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Alvelestat 848141-11-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Alvelestat 848141-11-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: AZD 9668 848141-11-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

848141-11-7, AZD 9668Related Search:

2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide Pazopanib Hydrochloride Cediranib CO-1686 AZD-9291 AZD2014

Alvelestat

AZD 9668

AZD9668

AZD-9668

Avelestat (AZD9668)

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

Avelestat

Alvelestat (AZD9668)

1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-Pyridinecarboxamide

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide Avelestat (AZD9668)

Cavosonstat

6-methyl-1-(3-methylphenyl)-5-(2-methylpyrazol-3-yl)-n-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxopyridine-3-carboxamide

AZD9668; AZD-9668; AZD 9668

CS-1060

3-Pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-

MPH-966)

Alvelestat-13C,d3

AZD-9668,Alvelestat,Elastase,AZD 9668,Inhibitor,inhibit

Alvelestat, 10 mM in DMSO

848141-11-7

Inhibitors