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AZD 9668

Product Name
AZD 9668
CAS No.
848141-11-7
Chemical Name
AZD 9668
Synonyms
AZD9668;CS-1060;AZD-9668;AZD 9668;MPH-966);Avelestat;Alvelestat;Cavosonstat;Alvelestat-13C,d3;Avelestat (AZD9668)
CBNumber
CB02668624
Molecular Formula
C25H22F3N5O4S
Formula Weight
545.53
MOL File
848141-11-7.mol
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AZD 9668 Property

Melting point:
207-209°C
Boiling point:
780.4±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
11.00±0.20(Predicted)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26083
Product name
AZD 9668
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
26083
Product name
AZD 9668
Packaging
25mg
Price
$426
Updated
2024/03/01
Cayman Chemical
Product number
26083
Product name
AZD 9668
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
26083
Product name
AZD 9668
Packaging
10mg
Price
$193
Updated
2024/03/01
TRC
Product number
A794660
Product name
Avelestat
Packaging
25mg
Price
$475
Updated
2021/12/16
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AZD 9668 Chemical Properties,Usage,Production

Description

AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.

Uses

Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.

target

NE

References

[1] stevens t, ekholm k, gränse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.

AZD 9668 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD 9668 Suppliers

China 76 India 2 United Kingdom 1 United States 11 Global 90
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View Lastest Price from AZD 9668 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Alvelestat 848141-11-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alvelestat 848141-11-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
AZD 9668 848141-11-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

848141-11-7, AZD 9668Related Search:

2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide Pazopanib Hydrochloride Cediranib CO-1686 AZD-9291 AZD2014

  • Alvelestat
  • AZD 9668
  • AZD9668
  • AZD-9668
  • Avelestat (AZD9668)
  • 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
  • Avelestat
  • Alvelestat (AZD9668)
  • 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-Pyridinecarboxamide
  • 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide Avelestat (AZD9668)
  • Cavosonstat
  • 6-methyl-1-(3-methylphenyl)-5-(2-methylpyrazol-3-yl)-n-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxopyridine-3-carboxamide
  • AZD9668; AZD-9668; AZD 9668
  • CS-1060
  • 3-Pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-
  • MPH-966)
  • Alvelestat-13C,d3
  • AZD-9668,Alvelestat,Elastase,AZD 9668,Inhibitor,inhibit
  • 848141-11-7
  • Inhibitors