5-Carboxy-8-hydroxyquinoline
- Product Name
- 5-Carboxy-8-hydroxyquinoline
- CAS No.
- 5852-78-8
- Chemical Name
- 5-Carboxy-8-hydroxyquinoline
- Synonyms
- IOX1;8-Hydroxyquinoline-5-carboxylic Acid;CS-1524;IOX-1;IOX 1;IOX 1, >=98%;5-Carboxy-8-hydroxyquinoline;JMJD2 Inhibitor, 5-carboxy-8HQ;8-hydroxy-5-Quinolinecarboxylic acid;5-Quinolinecarboxylic acid, 8-hydroxy-;5-Carboxy-8-hydroxyquinoline USP/EP/BP
- CBNumber
- CB02671446
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 5852-78-8.mol
5-Carboxy-8-hydroxyquinoline Property
- Melting point:
- 301 °C (decomp)
- Boiling point:
- 464.5±30.0 °C(Predicted)
- Density
- 1.480±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 1.82±0.10(Predicted)
- form
- powder
- color
- white to brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChIKey
- JGRPKOGHYBAVMW-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SML0067
- Product name
- IOX1
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $125
- Updated
- 2024/03/01
- Product number
- 420201
- Product name
- JMJD2 Inhibitor, 5-carboxy-8HQ
- Packaging
- 5mg
- Price
- $209
- Updated
- 2023/01/07
- Product number
- 11572
- Product name
- IOX1
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 11572
- Product name
- IOX1
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- SML0067
- Product name
- IOX1
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $200
- Updated
- 2024/03/01
5-Carboxy-8-hydroxyquinoline Chemical Properties,Usage,Production
Description
IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable
Uses
8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
Uses
IOX1 has been used:
- To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
- In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
- to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Uses
5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
Definition
ChEBI: 8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.
Biochem/physiol Actions
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at +4°C
References
1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535
5-Carboxy-8-hydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Carboxy-8-hydroxyquinoline manufacturers
- Product
- 5-Carboxy-8-hydroxyquinoline 5852-78-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20 tons
- Release date
- 2019-12-23