ChemicalBook > CAS DataBase List > 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

Product Name
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
CAS No.
881677-11-8
Chemical Name
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Synonyms
5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde;Vonoprazan N -1;5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity);Vonoprazan-10;Vonoprazan-026;TAK438 Impurity 67;Vonolazan impurity 12;TAK438 Intermediate 5;Sulfonyl aldehyde Impurity of Vonoprazan
CBNumber
CB02680972
Molecular Formula
C16H11FN2O3S
Formula Weight
330.33
MOL File
881677-11-8.mol
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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Property

Boiling point:
563.7±60.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
-0.34±0.11(Predicted)
color 
Pale Brown to Light Brown
InChI
InChI=1S/C16H11FN2O3S/c17-15-6-2-1-5-14(15)16-8-12(11-20)10-19(16)23(21,22)13-4-3-7-18-9-13/h1-11H
InChIKey
IXCSYEVJOAWXRH-UHFFFAOYSA-N
SMILES
N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(C=O)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D294328
Product name
3-Des-N-methylmethanamineVonoprazan-3-carbaldehyde
Packaging
500mg
Price
$255
Updated
2021/12/16
AK Scientific
Product number
2733EA
Product name
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Packaging
5g
Price
$658
Updated
2021/12/16
Crysdot
Product number
CD11035613
Product name
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Purity
97%
Packaging
5g
Price
$420
Updated
2021/12/16
Chemenu
Product number
CM176209
Product name
5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Purity
97%
Packaging
5g
Price
$533
Updated
2021/12/16
Alichem
Product number
881677118
Product name
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Packaging
5g
Price
$604.2
Updated
2021/12/16
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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Pale Brown to Light Brown Solid.

Uses

3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde is an impurity of Vonaprazan (V767010) a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

Synthesis

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde is prepared by the reaction of 3-pyridinesulfonyl Chloride and 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde. The specific synthesis steps are as follows:
Take 10.0g (52.86mmol) of compound, 5.9g (58.15mmol) of triethylamine and 100mL of dichloromethane, cool the system to 0°C, add dropwise a dichloromethane solution (100mL) of compound G (58.15mmol), and add dropwise After completion, the system was reacted at room temperature for 6 hours, 100mL of water was added and washed twice, the organic phase was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 16.4g of 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde, with a yield of 93.8%.

Solubility in organics

Chloroform (Slightly), DMSO (Slightly)

References

[1] Patent: CN106478601, 2017, A. Location in patent: Paragraph 0036; 0037
[2] Patent: EP2963019, 2016, A1. Location in patent: Paragraph 0142; 0146
[3] Patent: CN107586288, 2018, A. Location in patent: Paragraph 0035-0037
[4] Patent: US2018/186736, 2018, A1. Location in patent: Paragraph 0142; 0143
[5] Patent: US2011/306769, 2011, A1. Location in patent: Page/Page column 28-29

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 881677-11-8
Price
US $20.00/kg
Min. Order
1kg
Purity
99
Supply Ability
100000
Release date
2025-03-05
Wuhan Biocar Pharmacy CO.,Ltd.
Product
5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile 881677-11-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
800kg
Release date
2025-03-18
Shandong Xuhuang New material CoLTD
Product
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl) 881677-11-8
Price
US $150.00/KG
Min. Order
1KG
Purity
99.99%
Supply Ability
12T
Release date
2025-02-20

881677-11-8, 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehydeRelated Search:

(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 5-chloropyridine-3-sulfonyl chloride Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol 4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene N-(1-(naphthalen-1-yl)ethyl)forMaMide PYRIDINE-2-SULFONYL CHLORIDE 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 3-Pyridinesulfonic acid 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- 2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Vonoprazan 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile

  • 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
  • 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde
  • 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
  • 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldenhyde
  • 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde
  • TAK-438( Vonoprazan fumarate) intermediate 4
  • (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
  • Vonoprazan-026
  • TAK438 Impurity 67
  • Vonoprazan impurity 31/5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3- carbaldehyde
  • Vonoprazan N -1
  • Vonoprazan-10
  • 2-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)acetaldehyde
  • 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity)
  • 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carb...
  • 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbaldehyde
  • TAK438 Intermediate 5
  • 5- (2-Fluorophenyl)-1- (pyridine-3-sulphonyl)-1-H-pyrrole-3-carbaldehyde
  • Vonolazan impurity 12
  • 5-(2-Fluoropheny1)-1-[( pyridin -3- yl ) sulfonyl ]-1H- pyrrole -3- carboxaldehyde
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carba
  • Sulfonyl aldehyde Impurity of Vonoprazan
  • 5-(2-FluorophenyI)-1-[(py ridin-3-yl)sulfonyl]-1H-p yrrole-3-carboxaldehyde
  • 5-(2-Fluorophenyl)-1-(3-pyridylsulfonyl)pyrrole-3-carbaldehyde
  • 4-Des-(N-Methyl)aminomethyl Vonoprazan-4-carboxaldehyde
  • 881677-11-8
  • 881674-11-8
  • 881677-11-8