SDZ 220-581 (hydrochloride)

Product Name: SDZ 220-581 (hydrochloride)
CAS No.: 179411-93-9
Chemical Name: SDZ 220-581 (hydrochloride)
Synonyms: SDZ 220-581 (hydrochloride);SDZ 220-581 hydrochloride >=98% (HPLC);SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride;(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride
CBNumber: CB02682022
Molecular Formula: C16H18Cl2NO5P
Formula Weight: 406.2
MOL File: 179411-93-9.mol

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SDZ 220-581 (hydrochloride) Property

storage temp.: room temp
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige
optical activity: [α]/D -5 to -8°, c = 1 in 1 M HCl

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0598
Product name: SDZ 220-581 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0598
Product name: SDZ 220-581 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $515
Updated: 2022/05/15

AK Scientific

Product number: 4035AH
Product name: (S)-alpha-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoicacidhydrochloride
Packaging: 50mg
Price: $640
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS65164
Product name: SDZ 220-581 hydrochloride
Packaging: 50mg
Price: $437.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS65164
Product name: SDZ 220-581 hydrochloride
Packaging: 10mg
Price: $135
Updated: 2021/12/16

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SDZ 220-581 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

sdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2].

References

[1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.
[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669.

SDZ 220-581 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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SDZ 220-581 (hydrochloride) Suppliers

China 23 United Kingdom 2 United States 5 Global 30

Haoyuan Chemexpress Co., Ltd.

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TargetMol Chemicals Inc.

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DC Chemicals

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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SDZ 220-581 (hydrochloride)

(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride

(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride

SDZ 220-581 hydrochloride >=98% (HPLC)

SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride

179411-93-9

C16H17ClNO5PHCl

C16H18Cl2NO5P