2-Amino-5-chloropyridine
- Product Name
- 2-Amino-5-chloropyridine
- CAS No.
- 1072-98-6
- Chemical Name
- 2-Amino-5-chloropyridine
- Synonyms
- 5-CHLOROPYRIDIN-2-AMINE;5-CHLORO-2-AMINOPYRIDINE;80.8;AKOS 91155;TIMTEC-BB SBB000059;5-Chlor-2-pyridylamin;5-CHLORO-A-PYRIDYLAMINE;5-CHLORO-2-PYRIDYLAMINE;5-CHLORO-2-PYRIDINAMINE;2-Amino-5-Cloropyridine
- CBNumber
- CB0736206
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 1072-98-6.mol
2-Amino-5-chloropyridine Property
- Melting point:
- 135-138 °C (lit.)
- Boiling point:
- 127-128 °C/11 mmHg (lit.)
- Density
- 1.2417 (rough estimate)
- refractive index
- 1.5110 (estimate)
- Flash point:
- 160 °C
- storage temp.
- 2-8°C
- solubility
- 1.0g/l
- pka
- 4.67±0.13(Predicted)
- form
- Crystalline Powder
- color
- Beige to beige-brown
- Water Solubility
- 1 g/L (20 ºC)
- BRN
- 108735
- InChIKey
- MAXBVGJEFDMHNV-UHFFFAOYSA-N
- CAS DataBase Reference
- 1072-98-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Amino-5-chloropyridine(1072-98-6)
- EPA Substance Registry System
- 2-Amino-5-chloropyridine (1072-98-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A46803
- Product name
- 2-Amino-5-chloropyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $27.1
- Updated
- 2025/07/31
- Product number
- BP813
- Product name
- 2-Amino-5-chloropyridine
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 25MG
- Price
- $255
- Updated
- 2025/07/31
- Product number
- A46803
- Product name
- 2-Amino-5-chloropyridine
- Purity
- 98%
- Packaging
- 100g
- Price
- $82.9
- Updated
- 2025/07/31
- Product number
- A0837
- Product name
- 2-Amino-5-chloropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- A0837
- Product name
- 2-Amino-5-chloropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $91
- Updated
- 2025/07/31
2-Amino-5-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
beige to beige-brown crystalline powder
Uses
5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.
Reactions
2-Amino-5-chloropyridine can be used to electro-organically synthesize 6-aminonicotinic acid. 6-aminonicotinic acid is the main component of vitamin B3 and can be used to treat pellagra. The specific method is as follows:
In the presence of sulfuric acid and carbon dioxide, in dimethylformamide (DMF) solution, 5-chloro-2-nitropyridine 1 is electrochemically converted to 2-amino-5-chloropyridine 2 on a nickel cathode and a copper anode at an apparent current density of 10 mA/cm2 using a diaphragmless electrolytic cell, with a yield of up to 84%. Then 2 is reductively carboxylated to synthesize 6-aminonicotinic acid 3 on the cathode surface with a yield of 78%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020
Toxicology
2-Amino-5-chloropyridine is an irritant, causing severe eye irritation, possibly skin and respiratory irritation, and harmful if ingested. The substance is non-mutagenic, but has a relatively high toxicity to zebrafish embryonic development, with embryonic malformation and mortality rates being concentration-dependent.
Purification Methods
Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]
2-Amino-5-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-chloropyridine manufacturers
- Product
- 2-Amino-5-chloropyridine 1072-98-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000KGS
- Release date
- 2021-07-06
- Product
- 2-Amino-5-chloropyridine 1072-98-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2024-10-30
- Product
- 2-Amino-5-chloropyridine 1072-98-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-24