ChemicalBook > CAS DataBase List > 2-Amino-5-chloropyridine

2-Amino-5-chloropyridine

Product Name
2-Amino-5-chloropyridine
CAS No.
1072-98-6
Chemical Name
2-Amino-5-chloropyridine
Synonyms
5-CHLOROPYRIDIN-2-AMINE;5-CHLORO-2-AMINOPYRIDINE;80.8;AKOS 91155;TIMTEC-BB SBB000059;5-Chlor-2-pyridylamin;5-CHLORO-A-PYRIDYLAMINE;5-CHLORO-2-PYRIDYLAMINE;5-CHLORO-2-PYRIDINAMINE;2-Amino-5-Cloropyridine
CBNumber
CB0736206
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
1072-98-6.mol
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2-Amino-5-chloropyridine Property

Melting point:
135-138 °C (lit.)
Boiling point:
127-128 °C/11 mmHg (lit.)
Density 
1.2417 (rough estimate)
refractive index 
1.5110 (estimate)
Flash point:
160 °C
storage temp. 
2-8°C
solubility 
1.0g/l
pka
4.67±0.13(Predicted)
form 
Crystalline Powder
color 
Beige to beige-brown
Water Solubility 
1 g/L (20 ºC)
BRN 
108735
InChIKey
MAXBVGJEFDMHNV-UHFFFAOYSA-N
CAS DataBase Reference
1072-98-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Amino-5-chloropyridine(1072-98-6)
EPA Substance Registry System
2-Amino-5-chloropyridine (1072-98-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A46803
Product name
2-Amino-5-chloropyridine
Purity
98%
Packaging
25g
Price
$27.1
Updated
2025/07/31
Sigma-Aldrich
Product number
BP813
Product name
2-Amino-5-chloropyridine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$255
Updated
2025/07/31
Sigma-Aldrich
Product number
A46803
Product name
2-Amino-5-chloropyridine
Purity
98%
Packaging
100g
Price
$82.9
Updated
2025/07/31
TCI Chemical
Product number
A0837
Product name
2-Amino-5-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
A0837
Product name
2-Amino-5-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$91
Updated
2025/07/31
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2-Amino-5-chloropyridine Chemical Properties,Usage,Production

Chemical Properties

beige to beige-brown crystalline powder

Uses

5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Reactions

2-Amino-5-chloropyridine can be used to electro-organically synthesize 6-aminonicotinic acid. 6-aminonicotinic acid is the main component of vitamin B3 and can be used to treat pellagra. The specific method is as follows:
In the presence of sulfuric acid and carbon dioxide, in dimethylformamide (DMF) solution, 5-chloro-2-nitropyridine 1 is electrochemically converted to 2-amino-5-chloropyridine 2 on a nickel cathode and a copper anode at an apparent current density of 10 mA/cm2 using a diaphragmless electrolytic cell, with a yield of up to 84%. Then 2 is reductively carboxylated to synthesize 6-aminonicotinic acid 3 on the cathode surface with a yield of 78%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020

Toxicology

2-Amino-5-chloropyridine is an irritant, causing severe eye irritation, possibly skin and respiratory irritation, and harmful if ingested. The substance is non-mutagenic, but has a relatively high toxicity to zebrafish embryonic development, with embryonic malformation and mortality rates being concentration-dependent.

Purification Methods

Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]

2-Amino-5-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Zopiclone 5-Chloro-2-hydroxy-3-nitropyridine 2,5-Dichloro-3-nitropyridine 2,5-Dichloropyridin-3-amine
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2-Amino-5-chloropyridine Suppliers

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View Lastest Price from 2-Amino-5-chloropyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-5-chloropyridine 1072-98-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-07-06
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-5-chloropyridine 1072-98-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100
Release date
2024-10-30
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Amino-5-chloropyridine 1072-98-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-24

1072-98-6, 2-Amino-5-chloropyridineRelated Search:

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  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Building Blocks
  • Halopyridines
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  • Pyridines
  • FINE Chemical & INTERMEDIATES
  • Amines
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  • Nitrogen cyclic compounds
  • Heterocycle-Pyridine series
  • amine| alkyl chloride
  • Pyridines derivates
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  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
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