SDZ 220-581 (hydrochloride)
- Product Name
- SDZ 220-581 (hydrochloride)
- CAS No.
- 179411-93-9
- Chemical Name
- SDZ 220-581 (hydrochloride)
- Synonyms
- SDZ 220-581 (hydrochloride);SDZ 220-581 hydrochloride >=98% (HPLC);SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride;(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride
- CBNumber
- CB02682022
- Molecular Formula
- C16H18Cl2NO5P
- Formula Weight
- 406.2
- MOL File
- 179411-93-9.mol
SDZ 220-581 (hydrochloride) Property
- storage temp.
- room temp
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -5 to -8°, c = 1 in 1 M HCl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0598
- Product name
- SDZ 220-581 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $130
- Updated
- 2022/05/15
- Product number
- SML0598
- Product name
- SDZ 220-581 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $515
- Updated
- 2022/05/15
- Product number
- 4035AH
- Product name
- (S)-alpha-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoicacidhydrochloride
- Packaging
- 50mg
- Price
- $640
- Updated
- 2021/12/16
- Product number
- FS65164
- Product name
- SDZ 220-581 hydrochloride
- Packaging
- 50mg
- Price
- $437.5
- Updated
- 2021/12/16
- Product number
- FS65164
- Product name
- SDZ 220-581 hydrochloride
- Packaging
- 10mg
- Price
- $135
- Updated
- 2021/12/16
SDZ 220-581 (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
sdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2].
References
[1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.
[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669.