SIRT2 Inhibitor II, AK-1
- Product Name
- SIRT2 Inhibitor II, AK-1
- CAS No.
- 330461-64-8
- Chemical Name
- SIRT2 Inhibitor II, AK-1
- Synonyms
- CS-923;AK 1, >=98%;AK-1;AK1;AK 1;AK-1 >=98% (HPLC);AK-1, 10 mM in DMSO;AK-1, SIRT2 inhibitor;SIRT2 Inhibitor II, AK-1;inhibit,AK-1,AK 1,AK1,Inhibitor,Sirtuin;Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-;3-(azepane-1-sulfonyl)-N-(3-nitro-phenyl)-benzamide SIRT2 Inhibitor II, AK-1
- CBNumber
- CB02684460
- Molecular Formula
- C19H21N3O5S
- Formula Weight
- 403.45
- MOL File
- 330461-64-8.mol
SIRT2 Inhibitor II, AK-1 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.3 mg/ml
- form
- A crystalline solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 566331
- Product name
- SIRT2 Inhibitor II, AK-1
- Purity
- The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
- Packaging
- 10 mg
- Price
- $150
- Updated
- 2025/07/31
- Product number
- 21276
- Product name
- AK-1
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21276
- Product name
- AK-1
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21276
- Product name
- AK-1
- Packaging
- 25mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- CS-6310
- Product name
- AK-1
- Purity
- 99.81%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
SIRT2 Inhibitor II, AK-1 Chemical Properties,Usage,Production
Description
AK-1 is a SIRT2 Inhibitor II that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
Uses
AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
IC 50
SIRT2: 12.5 μM (IC50)
References
[1] Ruth Luthi-Carter, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. DOI:10.1073/pnas.1002924107
[2] Lee SD, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016 Apr 1;373(1):138-45. DOI:10.1016/j.canlet.2016.01.031
[3] Luthi-Carter R, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
[4] David M. Taylor, et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. DOI:10.1021/cb100376q
[5] Cheon MG, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. DOI:10.1016/j.canlet.2014.10.012
SIRT2 Inhibitor II, AK-1 Preparation Products And Raw materials
Raw materials
Preparation Products
SIRT2 Inhibitor II, AK-1 Suppliers
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View Lastest Price from SIRT2 Inhibitor II, AK-1 manufacturers
- Product
- SIRT2 Inhibitor II, AK-1 330461-64-8
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-27