ChemicalBook > CAS DataBase List > YM 2447690

YM 2447690

Product Name
YM 2447690
CAS No.
837424-39-2
Chemical Name
YM 2447690
Synonyms
YM 244769;YM 2447690;YM-244769 hydrochloride;N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
CBNumber
CB02701747
Molecular Formula
C27H24ClFN2O3
Formula Weight
478.9424632
MOL File
837424-39-2.mol
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YM 2447690 Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 100 mM in DMSO
form 
Powder
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4544
Product name
YM244769
Purity
≥99%(HPLC)
Packaging
10
Price
$191
Updated
2021/12/16
Tocris
Product number
4544
Product name
YM244769
Purity
≥99%(HPLC)
Packaging
50
Price
$823
Updated
2021/12/16
Usbiological
Product number
257147
Product name
YM 244769
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
Y100565
Product name
YM2447690
Packaging
50mg
Price
$550
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
49253
Product name
YM2447690
Packaging
10mg
Price
$640
Updated
2021/12/16
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YM 2447690 Chemical Properties,Usage,Production

Uses

YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. This compound has neuroprotective properties.

in vivo

YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2].

Animal Model:Wild-type C57BL/6J mice and NCX-KO mice[2]
Dosage:0.1, 0.3 and 1 mg/kg
Administration:Oral administration, once
Result:Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO.

YM 2447690 Preparation Products And Raw materials

Raw materials

Preparation Products

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YM 2447690 Suppliers

Canada 1 China 20 India 1 United Kingdom 1 United States 5 USA 1 Global 29
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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Jinan ponder chemical co. LTD
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0531-0000
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thinklifescience@163.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Suzhou Zhixin Biotechnology Co., Ltd.
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0512-65118909 18100677375
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sales@szzxbio.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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Santa Cruz Biotechnology Inc
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021-60936350
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
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0571-85806285
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sales@molcore.com
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Guangzhou Tuoshan Biotechnology Co., Ltd.
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19928332050
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Shenzhen Science Biology Co., Ltd.
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18617181553
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Guangzhou Squirrel Biotechnology Co., Ltd.
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17765276361
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Chongqing Boer Biotechnology Co., Ltd.
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13251428727， 13368356747
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Beijing Shengke Boyuan Biotechnology Co., Ltd.
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Shanghai yiji industries Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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837424-39-2, YM 2447690Related Search:

3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- YM-244769 dihydrochloride

  • N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
  • YM 2447690
  • YM 244769
  • YM-244769 hydrochloride
  • 837424-39-2
  • C26H22FN3O32HCl