ChemicalBook > CAS DataBase List > YM 2447690
YM 2447690
- Product Name
- YM 2447690
- CAS No.
- 837424-39-2
- Chemical Name
- YM 2447690
- Synonyms
- YM 244769;YM 2447690;YM-244769 hydrochloride;N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
- CBNumber
- CB02701747
- Molecular Formula
- C27H24ClFN2O3
- Formula Weight
- 478.9424632
- MOL File
- 837424-39-2.mol
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YM 2447690 Property
- storage temp.
- Desiccate at RT
- solubility
- Soluble to 100 mM in DMSO
- form
- Powder
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
Tocris
- Product number
- 4544
- Product name
- YM244769
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $191
- Updated
- 2021/12/16
Tocris
- Product number
- 4544
- Product name
- YM244769
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $823
- Updated
- 2021/12/16
Usbiological
- Product number
- 257147
- Product name
- YM 244769
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
TRC
- Product number
- Y100565
- Product name
- YM2447690
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 49253
- Product name
- YM2447690
- Packaging
- 10mg
- Price
- $640
- Updated
- 2021/12/16
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YM 2447690 Chemical Properties,Usage,Production
Uses
YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. This compound has neuroprotective properties.
in vivo
YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2].
| Animal Model: | Wild-type C57BL/6J mice and NCX-KO mice[2] |
| Dosage: | 0.1, 0.3 and 1 mg/kg |
| Administration: | Oral administration, once |
| Result: | Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO. |
YM 2447690 Preparation Products And Raw materials
Raw materials
Preparation Products
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YM 2447690 Suppliers
837424-39-2, YM 2447690Related Search:
3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-
YM-244769 dihydrochloride