(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Product Name: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
CAS No.: 365997-33-7
Chemical Name: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
Synonyms: Edoxaban Impurity N47;Ethyl rel-(1R,3S,4S)-3-azido-4-hydroxycyclohexanecarboxylate;Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]...;(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester;Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate;3-(3-(Trifluoromethyl)phenyl)propan-1-ol (Intermediate of Cinacalcet hydrochloride);TIANFU CHEM-- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester;(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylic acid ethyl ester;Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-, ethyl ester,(1S,3R,4R)-;ethyl (1S,3R,4R)-3-((tert- butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate (Intermediate of Edoxaban mesylate)
CBNumber: CB02703877
Molecular Formula: C14H25NO5
Formula Weight: 287.35
MOL File: 365997-33-7.mol

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(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Property

Melting point:: 93-95°C
Boiling point:: 406.6±45.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 11.73±0.60(Predicted)
color: White to Off-White
optical activity: 29.6°(C=0.01g/mL, CHCL3, 20°C, 589nm)
InChI: InChI=1S/C14H25NO5/c1-5-19-12(17)9-6-7-11(16)10(8-9)15-13(18)20-14(2,3)4/h9-11,16H,5-8H2,1-4H3,(H,15,18)/t9-,10+,11+/m0/s1
InChIKey: YFFMJGAVWORNIZ-HBNTYKKESA-N
SMILES: [C@H]1(C(OCC)=O)CC[C@@H](O)[C@H](NC(OC(C)(C)C)=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E927835
Product name: Ethyl(1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate
Packaging: 2.5g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 9770AF
Product name: (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
Packaging: 10g
Price: $184
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0065794
Product name: (1S,3R,4R)-3-(BOC-AMINO)-4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $499.94
Updated: 2021/12/16

AK Scientific

Product number: 9770AF
Product name: (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
Packaging: 100g
Price: $691
Updated: 2021/12/16

Matrix Scientific

Product number: 122061
Product name: (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
Purity: 97.0%
Packaging: 1g
Price: $1073
Updated: 2021/12/16

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(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Chemical Properties,Usage,Production

Uses

(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.

Preparation

Under 45°C, aqueous ammonia(175 mL) was added to the (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate ethyl (17g, 0.1mmol). After TLC confirmed that the reaction was completed, the reaction liquid was vacuum concentrated. Then 175 mL ethanol was added to the reaction. At room temperature, di-tert-butyl dicarbonate (44.0g, 201mmol) dissolved in ethanol would be added to the above mixture. After reaction for 1h, the solid was concentrated in vacuo, and water (300 mL) was added to the mixture.The water layer was extracted with ethanol (300 mL) twice. The organic phase was collected and dried with anhydrous sodium sulfate. After vacuum concentration, the residue was purified by column chromatography on silica gel to obtain (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester.

(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Suppliers

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View Lastest Price from (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester 365997-33-7
Price: US $0.00-0.00/KG
Min. Order: 0.001KG
Purity: 99.99%
Supply Ability: 200000T
Release date: 2025-06-16

Career Henan Chemical Co

Product: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester 365997-33-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

365997-33-7, (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl esterRelated Search:

(1S,3S,4S)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester carbamic acid, n-[(1r,2r,5s)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (1R,3R,4R)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Rivaroxaban intermediate Edoxaban Impurity 16 Edoxaban tosylate monohydrate 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-, ethyl ester,(1S,3R,4R)-

Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate

(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylic acid ethyl ester

(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]...

TIANFU CHEM-- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Ethyl rel-(1R,3S,4S)-3-azido-4-hydroxycyclohexanecarboxylate

Edoxaban Impurity N47

3-(3-(Trifluoromethyl)phenyl)propan-1-ol (Intermediate of Cinacalcet hydrochloride)

ethyl (1S,3R,4R)-3-((tert- butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate (Intermediate of Edoxaban mesylate)

365997-33-7