2-(Boc-aMino)-4-Methylthiophene
- Product Name
- 2-(Boc-aMino)-4-Methylthiophene
- CAS No.
- 887475-43-6
- Chemical Name
- 2-(Boc-aMino)-4-Methylthiophene
- Synonyms
- 2-(Boc-aMino)-4-Methylthiophene;tert-Butyl (4-methylthiophen-2-yl)carbamate;tert-butyl N-(4-methylthiophen-2-yl)carbamate;Carbamic acid, (4-methyl-2-thienyl)-, 1,1-dimethylethyl ester;Carbamic acid, N-(4-methyl-2-thienyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB02704117
- Molecular Formula
- C10H15NO2S
- Formula Weight
- 213.3
- MOL File
- 887475-43-6.mol
2-(Boc-aMino)-4-Methylthiophene Property
- Boiling point:
- 254.6±28.0 °C(Predicted)
- Density
- 1.157±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 13.63±0.70(Predicted)
- Appearance
- Off-white to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B704193
- Product name
- 2-(Boc-amino)-4-methylthiophene
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 8H66-1-4A
- Product name
- 2-(Boc-amino)-4-methylthiophene
- Packaging
- 1g
- Price
- $494
- Updated
- 2021/12/16
- Product number
- CHM1554543
- Product name
- 2-(BOC-AMINO)-4-METHYLTHIOPHENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.71
- Updated
- 2021/12/16
- Product number
- 113006
- Product name
- 2-(Boc-amino)-4-methylthiophene
- Packaging
- 1g
- Price
- $564
- Updated
- 2021/12/16
- Product number
- 113006
- Product name
- 2-(Boc-amino)-4-methylthiophene
- Packaging
- 5g
- Price
- $1713
- Updated
- 2021/12/16
2-(Boc-aMino)-4-Methylthiophene Chemical Properties,Usage,Production
Synthesis
14282-78-1
75-65-0
887475-43-6
General procedure for the synthesis of tert-butyl (4-methylthiophen-2-yl)carbamate from 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol) and tert-butanol: 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol), diphenylphosphoryl azide (1.94 g, 7.03 mmol) and triethylamine (0.98 mL. 7.03 mmol) were dissolved in tert-butanol (20 mL) and heated to reflux for 5 hours. Upon completion of the reaction, confirmation was monitored by thin layer chromatography (unfolding agent: dichloromethane/hexane). The reaction mixture was cooled to room temperature, poured into water and extracted with ether (3 x 20 mL). The ether extracts were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a beige solid. Purification by silica gel column chromatography (eluent: hexane/dichloromethane) afforded the target compound tert-butyl (4-methylthiophen-2-yl)carbamate (0.96 g, yield 64%) as a white solid.1H-NMR (400 MHz, DMSO-d6) δ 6.42 (s, 1H), 6.35 (d, 1H), 1.46 (s, 9H).
References
[1] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151
[2] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 77
[3] Patent: WO2013/78468, 2013, A1. Location in patent: Paragraph 0800
2-(Boc-aMino)-4-Methylthiophene Preparation Products And Raw materials
Raw materials
Preparation Products
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