ChemicalBook > CAS DataBase List > (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide

Product Name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
CAS No.
368421-58-3
Chemical Name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
Synonyms
(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide;(2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide; 368421-58-3;1H-1,2,4-Triazole-1-butanethioamide, β-(2,5-difluorophenyl)-β-hydroxy-α-methyl-, (αR,βR)-;3R)-3-(2;ISAVUCONAZOLE IST-1;Isavuconazole Impuirty G;Isavuconazole Impurity G;Ixaconazole intermediate;Aishakang Intermediate 8
CBNumber
CB02709066
Molecular Formula
C13H14F2N4OS
Formula Weight
312.34
MOL File
368421-58-3.mol
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(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Property

Melting point:
198-200oC
Boiling point:
536.4±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.54±0.29(Predicted)
color 
Off-White
InChI
InChI=1/C13H14F2N4OS/c1-8(12(16)21)13(20,5-19-7-17-6-18-19)10-4-9(14)2-3-11(10)15/h2-4,6-8,20H,5H2,1H3,(H2,16,21)/t8-,13+/s3
InChIKey
UWVOPVUWKIHGRF-MKHMJDPCNA-N
SMILES
C(=S)(N)[C@H](C)[C@](C1=CC(F)=CC=C1F)(O)CN1C=NC=N1 |&1:3,5,r|
CAS DataBase Reference
368421-58-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D446345
Product name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide
Packaging
1mg
Price
$150
Updated
2021/12/16
Ark Pharm
Product number
P000096376
Product name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Purity
97%
Packaging
100mg
Price
$17
Updated
2021/12/16
Ark Pharm
Product number
P000096376
Product name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Purity
97%
Packaging
250mg
Price
$25
Updated
2021/12/16
ChemScene
Product number
CS-M3468
Product name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide
Packaging
1g
Price
$61
Updated
2021/12/16
Ark Pharm
Product number
P000096376
Product name
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Purity
97%
Packaging
1g
Price
$62
Updated
2021/12/16
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(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Chemical Properties,Usage,Production

Uses

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide is an intermediate in the synthesis of Isavuconazole (I777830), an triazole based antifungal agent for the treatment of invasive fungal infections.

Synthesis

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide is prepared by passing (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile and O,O-Diethyl hydrogen phosphorodithioate through the following steps.
Step 1: (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile; O,O-Diethyl hydrogen phosphorodithioate In water; isopropyl alcohol at 78℃; for 15h;
Step 2: With sodium hydroxide In dichloromethane; water at 20℃; pH=7-8.

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Suppliers

China 269 India 4 United States 5 Global 278
Nantong Nuotai Biomedical Technology Co., Ltd.
Tel
0513-82206272 17706270880
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2057095228@qq.com
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China
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Chengdu Better Pharmaceutical Technology Co.,Ltd.
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18280102635; 18280102635
Fax
028-82252524
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sales@betterwanhe.com
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China
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Nanjing Vcare PharmaTech Co., Ltd
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025-58741518 13327700685
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sales@vcarepharmatech.com
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China
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496
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Tai Zhou World Pharm & Chem Co., Ltd
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0576-85301198 13736201658
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16029347@qq.com
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China
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Tianjin Liontec Biopharma Co.,Ltd.
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022-87601716 13920326762
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yzhang@liontec.com.cn
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China
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61
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58
Beijing Hope Pharmaceutical Co., Ltd.
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010-67886402 15600038801
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wuhangjin@hopelife.cn
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China
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85
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Shanghai Yanze Chemical Co., Ltd
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021-13621551597 19962611955
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260924549@qq.com
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China
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1633
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
Fax
86-025-86918232
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sales@pharmablock.com
Country
China
ProdList
5000
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55
Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
Email
chenyj@titansci.com
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China
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View Lastest Price from (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 368421-58-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Isavuconazole Impurity 36 368421-58-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2025-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 368421-58-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10kg/month
Release date
2022-12-28

368421-58-3, (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMideRelated Search:

Isavuconazonium sulfate

  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
  • NaMe:Isavuconazole interMediate 8
  • (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide
  • (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate monohydrate
  • Isavuconazole intermediate 8
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide Hydrate Hydrosulfate
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMid
  • Isavuconazole intermediate 8 ? ?(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide
  • Isoxaconazole Intermediate 8
  • 3R)-3-(2
  • 4-triazol-1-yl)thiobutyraMide
  • 5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutraMide
  • (2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
  • Isavuconazole Impuirty G
  • 368421-58-3
  • 1H-1,2,4-Triazole-1-butanethioamide, β-(2,5-difluorophenyl)-β-hydroxy-α-methyl-, (αR,βR)-
  • ISAVUCONAZOLE IST-1
  • Isavuconazole Impurity G
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,...
  • Ixaconazole intermediate
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMideIsavuconazole intermediate 8
  • (2R,3R)-3-(2,5 di fluorophenyl) -3-hydroxy -2-methyl-4-(1,2,4-triazol -1- yl)butanethioamide
  • (2R, 3R) -3- (2,5-difluorophenyl) -3-hydroxy-2-methyl-4- (1H-1,2,4-triazol-1-yl) thiobutanamide
  • Aishakang Intermediate 8
  • Isavuconazole Related Compound 12
  • 2R, 3R) – 3 – (2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazole-yl) butane thioamide
  • ISAVUCONAZOLE INTERMEDIATE M8
  • (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutanamidesulfatemonohydrate
  • Isavuconazole intermediates8
  • 368421-58-3
  • C13H14F2N4OS
  • Isavuconazonium sulfate
  • ZJ