Isavuconazonium sulfate

Product Name: Isavuconazonium sulfate
CAS No.: 946075-13-4
Chemical Name: Isavuconazonium sulfate
Synonyms: Isavuconazon;ISAVUCONAZOLE SULFATE;BAL 8557-002;Edoxaban Free Base;savuconazonium Sulfate;lsavuconazonium sulfate;API-Antifungal Infection;Isavuconazonium sulfate (BAL8557);Isavuconazole Impurity 40 Sulphite;Isavuconazole Impurity 45 Sulphite
CBNumber: CB42748579
Molecular Formula: C35H36F2N8O9S2
Formula Weight: 814.84
MOL File: 946075-13-4.mol

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Isavuconazonium sulfate Property

storage temp.: Store at -20°C
solubility: DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM)
form: A crystalline solid
InChIKey: LWXUIUUOMSMZKJ-XHOYWDQFNA-M
SMILES: S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3188
Product name: Isavuconazonium sulfate
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $89
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3188
Product name: Isavuconazonium sulfate
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $359
Updated: 2024/03/01

Cayman Chemical

Product number: 23950
Product name: Isavuconazonium (sulfate)
Purity: ≥95%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 23950
Product name: Isavuconazonium (sulfate)
Purity: ≥95%
Packaging: 1mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 23950
Product name: Isavuconazonium (sulfate)
Purity: ≥95%
Packaging: 5mg
Price: $477
Updated: 2024/03/01

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Isavuconazonium sulfate Chemical Properties,Usage,Production

Description

Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash.

Uses

Isavuconazonium Sulfate can be prepared to be used as an antifungal drug.

Definition

ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.

Metabolism

Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1].

References

[1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0.

Isavuconazonium sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isavuconazonium sulfate Suppliers

China 164 India 6 United Kingdom 1 United States 6 Global 177

Porton Pharma Solutions Ltd.

Tel: 23-86083200-6540
Fax: 023860832006830
Email: jia.chen@portonpharma.com
Country: China
ProdList: 56
Advantage: 58

Nanjing Vcare PharmaTech Co., Ltd

Tel: 025-58741518 17366379912
Email: sales@vcarepharmatech.com
Country: China
ProdList: 462
Advantage: 58

Shanghai Minkai Biological Technology Co., Ltd

Tel: 021-52919136 17315815539
Email: 2804155403@qq.com
Country: China
ProdList: 169
Advantage: 58

Beijing Hope International Pharmaceutical Technology Development Co., Ltd

Tel: 010-010-67886402 15600038801
Fax: 010-67887110-8016
Email: wuhangjin@hopelife.cn
Country: China
ProdList: 44
Advantage: 58

Anhui Enbang Biological Technology Co., Ltd.

Tel: 0551-68936860-8515 15357955825
Fax: 0551-68936860
Email: 15357955825@163.com
Country: China
ProdList: 81
Advantage: 55

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85929779 18980797963
Email: lijinxi@d-innovation.com
Country: China
ProdList: 263
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 027-027-52344656 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 3000
Advantage: 58

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Synches Co., Ltd.

Tel: 021-53292253
Fax: 021-53292253
Email: biz@synches.com
Country: China
ProdList: 200
Advantage: 64

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View Lastest Price from Isavuconazonium sulfate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Isavuconazonium sulfate 946075-13-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-13

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Isavuconazonium sulfate 946075-13-4
Price: US $0.10-0.30/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-02-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Isavuconazonium sulfate 946075-13-4
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10kg
Release date: 2022-12-28

946075-13-4, Isavuconazonium sulfateRelated Search:

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Isavuconazole Impurity (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 4-(2-((2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile isavuconazonium chloride Isavuconazole Tiotropium bromide KP 103 Aprepitant Voriconazole Posaconazole

Isavuconazon

BAL 8557-002

N-Methylglycine [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester sulfate (1:1)

API-Antifungal Infection

savuconazonium Sulfate

Edoxaban Free Base

ISAVUCONAZOLE SULFATE

Isavuconazonium sulfate (BAL8557)

Isavuconazonium sulfate,inhibit,antifungal,prodrug,aspergillosis,BAL8557-002,Fungal,mucormycosis,invasive,Isavuconazonium,Inhibitor,infections

Isavuconazole Impurity 40 Sulphite

1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium hydrogen sulfate

lsavuconazonium sulfate

Isavuconazole Impurity 45 Sulphite

946075-13-4

C35H35F2N8O5SHO4S

C35H36F2N8O9S2

C35H35F2N8O5SHSO4

API