Isavuconazonium sulfate
- Product Name
- Isavuconazonium sulfate
- CAS No.
- 946075-13-4
- Chemical Name
- Isavuconazonium sulfate
- Synonyms
- Isavuconazon;ISAVUCONAZOLE SULFATE;BAL 8557-002;Edoxaban Free Base;Isaaconazole sulfate;Escaconazole sulfate;savuconazonium Sulfate;lsavuconazonium sulfate;Isavuconazonium sulfate;Isavuconaconiun sulfate
- CBNumber
- CB42748579
- Molecular Formula
- C35H36F2N8O9S2
- Formula Weight
- 814.84
- MOL File
- 946075-13-4.mol
Isavuconazonium sulfate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM) - form
- A crystalline solid
- color
- White to off-white
- InChIKey
- LWXUIUUOMSMZKJ-XHOYWDQFNA-M
- SMILES
- S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML3188
- Product name
- Isavuconazonium sulfate
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $89
- Updated
- 2024/03/01
- Product number
- SML3188
- Product name
- Isavuconazonium sulfate
- Purity
- ≥95% (HPLC)
- Packaging
- 25MG
- Price
- $359
- Updated
- 2024/03/01
- Product number
- 23950
- Product name
- Isavuconazonium (sulfate)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 23950
- Product name
- Isavuconazonium (sulfate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 23950
- Product name
- Isavuconazonium (sulfate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $477
- Updated
- 2024/03/01
Isavuconazonium sulfate Chemical Properties,Usage,Production
Description
Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash.
Uses
Isavuconazonium Sulfate can be prepared to be used as an antifungal drug.
Definition
ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.
Metabolism
Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1].
References
[1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0.
Isavuconazonium sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Isavuconazonium sulfate Suppliers
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View Lastest Price from Isavuconazonium sulfate manufacturers
- Product
- Isavuconazonium sulfate 946075-13-4
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2024-07-17
- Product
- Isavuconazonium Sulfate 946075-13-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 50kg/Month
- Release date
- 2024-09-19
- Product
- Isavuconazonium sulfate 946075-13-4
- Price
- US $0.10-0.30/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-02-04