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Isavuconazonium sulfate

Product Name
Isavuconazonium sulfate
CAS No.
946075-13-4
Chemical Name
Isavuconazonium sulfate
Synonyms
Isavuconazon;ISAVUCONAZOLE SULFATE;BAL 8557-002;Edoxaban Free Base;Isaaconazole sulfate;Escaconazole sulfate;savuconazonium Sulfate;lsavuconazonium sulfate;Isavuconazonium sulfate;Isavuconaconiun sulfate
CBNumber
CB42748579
Molecular Formula
C35H36F2N8O9S2
Formula Weight
814.84
MOL File
946075-13-4.mol
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Isavuconazonium sulfate Property

storage temp. 
Store at -20°C
solubility 
DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
InChIKey
LWXUIUUOMSMZKJ-XHOYWDQFNA-M
SMILES
S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3188
Product name
Isavuconazonium sulfate
Purity
≥95% (HPLC)
Packaging
5MG
Price
$89
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3188
Product name
Isavuconazonium sulfate
Purity
≥95% (HPLC)
Packaging
25MG
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
23950
Product name
Isavuconazonium (sulfate)
Purity
≥95%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
23950
Product name
Isavuconazonium (sulfate)
Purity
≥95%
Packaging
1mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
23950
Product name
Isavuconazonium (sulfate)
Purity
≥95%
Packaging
5mg
Price
$477
Updated
2024/03/01
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Isavuconazonium sulfate Chemical Properties,Usage,Production

Description

Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash.

Uses

Isavuconazonium Sulfate can be prepared to be used as an antifungal drug.

Definition

ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.

Metabolism

Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1].

References

[1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0.

Isavuconazonium sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isavuconazonium sulfate Suppliers

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View Lastest Price from Isavuconazonium sulfate manufacturers

Moxin Chemicals
Product
Isavuconazole Sulfate 946075-13-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
100000
Release date
2025-01-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Isavuconazonium sulfate 946075-13-4
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99%
Supply Ability
10kg
Release date
2024-07-17
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Isavuconazonium Sulfate 946075-13-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-09-19

946075-13-4, Isavuconazonium sulfateRelated Search:

(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Isavuconazole Impurity (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 4-(2-((2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile isavuconazonium chloride Isavuconazole Tiotropium bromide KP 103 Aprepitant Voriconazole Posaconazole

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  • 1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium hydrogen sulfate
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  • 946075-13-4
  • C35H35F2N8O5SHO4S
  • C35H36F2N8O9S2
  • C35H35F2N8O5SHSO4
  • API