Methyl 4-cyano-2-fluoro-5-nitrobenzoate
- Product Name
- Methyl 4-cyano-2-fluoro-5-nitrobenzoate
- CAS No.
- 1149388-51-1
- Chemical Name
- Methyl 4-cyano-2-fluoro-5-nitrobenzoate
- Synonyms
- Methyl 4-cyano-2-fluoro-5-nitrobenzoate;4-Cyano-2-fluoro-5-nitro-benzoic acid methyl ester;Benzoic acid, 4-cyano-2-fluoro-5-nitro-, methyl ester
- CBNumber
- CB02710172
- Molecular Formula
- C9H5FN2O4
- Formula Weight
- 224.15
- MOL File
- 1149388-51-1.mol
Methyl 4-cyano-2-fluoro-5-nitrobenzoate Property
- Boiling point:
- 397.3±42.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to yellow Solid
N-Bromosuccinimide Price
- Product number
- 4439DT
- Product name
- Methyl4-cyano-2-fluoro-5-nitrobenzoate
- Packaging
- 250mg
- Price
- $286
- Updated
- 2021/12/16
- Product number
- A382895
- Product name
- Methyl4-cyano-2-fluoro-5-nitrobenzoate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- BB20-5705
- Product name
- 4-Cyano-2-fluoro-5-nitro-benzoicacidmethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- CD12178241
- Product name
- Methyl4-cyano-2-fluoro-5-nitrobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $429
- Updated
- 2021/12/16
- Product number
- 61-11168
- Product name
- Methyl4-cyano-2-fluoro-5-nitrobenzoate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
Methyl 4-cyano-2-fluoro-5-nitrobenzoate Chemical Properties,Usage,Production
Synthesis
175596-01-7
1149388-51-1
Step 3: To a reaction flask containing methyl 4-cyano-2-fluorobenzoate (1.61 g, 9.0 mmol), fuming nitric acid (15 mL) was slowly added, followed by dropwise addition of concentrated sulfuric acid (4 mL). The reaction mixture was stirred at 45 °C for 15 h and cooled to room temperature upon completion. The reaction solution was slowly poured into ice water and the aqueous phase was extracted with ethyl acetate (2×). The organic phases were combined, washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the target product methyl 4-cyano-2-fluoro-5-nitrobenzoate (859 mg, 3.83 mmol, 43% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.95 (d, 1H), 7.72 (d, 1H), 4.04 (s, 3H); the result of mass spectrometry (EI) analysis was consistent with the molecular weight of C9H5FN2O4: 224 (M+).
References
[1] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 447-448
Methyl 4-cyano-2-fluoro-5-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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