Methyl 2-cyano-3-Methylbenzoate

Product Name: Methyl 2-cyano-3-Methylbenzoate
CAS No.: 500024-27-1
Chemical Name: Methyl 2-cyano-3-Methylbenzoate
Synonyms: Methyl 2-cyano-3-Methylbenzoate;2-Cyano-3-methyl-benzoic acid methyl ester;Benzoic acid, 2-cyano-3-methyl-, methyl ester
CBNumber: CB02710480
Molecular Formula: C10H9NO2
Formula Weight: 175.18
MOL File: 500024-27-1.mol

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Methyl 2-cyano-3-Methylbenzoate Property

Boiling point:: 316.4±30.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific

Product number: 2498DA
Product name: Methyl2-cyano-3-methylbenzoate
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Ambeed

Product number: A142200
Product name: Methyl2-cyano-3-methylbenzoate
Purity: 98+%
Packaging: 5g
Price: $151
Updated: 2021/12/16

Chemenu

Product number: CM131434
Product name: methyl2-cyano-3-methylbenzoate
Purity: 95%
Packaging: 1g
Price: $299
Updated: 2021/12/16

Chemcia Scientific

Product number: BB20-4668
Product name: 2-Cyano-3-methyl-benzoicacidmethylester
Purity: ＞97%
Packaging: 1g
Price: $300
Updated: 2021/12/16

Crysdot

Product number: CD12067921
Product name: Methyl2-cyano-3-methylbenzoate
Purity: 95+%
Packaging: 1g
Price: $317
Updated: 2021/12/16

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Methyl 2-cyano-3-Methylbenzoate Chemical Properties,Usage,Production

Synthesis

557-21-1

131001-86-0

500024-27-1

General procedure for the synthesis of methyl 2-cyano-3-methylbenzoate from zinc cyanide and methyl 2-bromo-3-methylbenzoate: Intermediate 8: 2-(bromomethyl)-6-methylbenzonitrile Step 1: Synthesis of methyl 2-cyano-3-methylbenzoate Methyl 2-bromo-3-methylbenzoate (5 g, 21.8 mmol), Zn(CN)2 (10.26 g, 87.3 mmol) and Pd(PPh3)4 (1.51 g, 1.3 mmol) were dissolved in DMF (60 mL) and the reaction was stirred at 80 °C under nitrogen protection overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in dichloromethane (100 mL) and washed with water (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=10:1) to afford methyl 2-cyano-3-methylbenzoate (1.6 g, 43% yield) as a white solid. Product Characterization: 1H NMR (400 MHz, CD3OD) δ 7.97-7.95 (m, 1H), 7.68-7.62 (m, 2H), 3.96 (s, 3H), 2.60 (s, 3H); ES-LCMS m/z: 176.1 (M + H).

References

[1] Patent: WO2013/177349, 2013, A2. Location in patent: Page/Page column 42

Methyl 2-cyano-3-Methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-cyano-3-Methylbenzoate Suppliers

China 25 India 1 United States 3 Global 29

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500024-27-1, Methyl 2-cyano-3-MethylbenzoateRelated Search:

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500024-27-1