AZD5423
- Product Name
- AZD5423
- CAS No.
- 1034148-04-3
- Chemical Name
- AZD5423
- Synonyms
- AZD5423;AZD 5423;AZD-5423;AZD5423, 10 mM in DMSO;AZD 5423,AZD5423,Inhibitor,Glucocorticoid Receptor,inhibit,AZD-5423;2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide;2,2,2-Trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide;Acetamide, 2,2,2-trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]-
- CBNumber
- CB02714660
- Molecular Formula
- C25H21F4N3O3
- Formula Weight
- 487.45
- MOL File
- 1034148-04-3.mol
AZD5423 Property
- Boiling point:
- 573.8±50.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (205.15 mM; Need ultrasonic)
- pka
- 10.39±0.46(Predicted)
- form
- Solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0027671
- Product name
- AZD5423
- Purity
- 99.85%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-0027671
- Product name
- AZD5423
- Purity
- 99.85%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- API0018395
- Product name
- AZD-5423
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.71
- Updated
- 2021/12/16
- Product number
- CS-0027671
- Product name
- AZD5423
- Purity
- 99.85%
- Packaging
- 50mg
- Price
- $770
- Updated
- 2021/12/16
- Product number
- CS-0027671
- Product name
- AZD5423
- Purity
- 99.85%
- Packaging
- 100mg
- Price
- $1350
- Updated
- 2021/12/16
AZD5423 Chemical Properties,Usage,Production
Uses
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2].
References
[1] Werkstr?m V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. DOI:10.1111/bcpt.12621
[2] Gauvreau GM, et al. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. DOI:10.1164/rccm.201404-0623OC
AZD5423 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD5423 Suppliers
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