AZD1283

Product Name: AZD1283
CAS No.: 919351-41-0
Chemical Name: AZD1283
Synonyms: AZD1283;CS-1176;AZD1283, >98%;AZD-1283;AZD 1283;AZD1283 , CID23649325;AZD1283, 10 mM in DMSO;Ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate;ETHYL 6-(4-{[(BENZYLSULFONYL)AMINO]CARBONYL}PIPERIDIN-1-YL)-5-CYANO-2-METHYLNICOTINATE;ethyl 6-[4-(benzylsulfonylcarbamoyl)-1-piperidyl]-5-cyano-2-methyl-pyridine-3-carboxylate;6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester
CBNumber: CB02715612
Molecular Formula: C23H26N4O5S
Formula Weight: 470.54
MOL File: 919351-41-0.mol

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AZD1283 Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥18.15 mg/mL in DMSO
form: solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27649
Product name: AZD 1283
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 27649
Product name: AZD 1283
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 27649
Product name: AZD 1283
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27649
Product name: AZD 1283
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Tocris

Product number: 6085
Product name: AZD1283
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

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AZD1283 Chemical Properties,Usage,Production

Uses

AZD 1283 is a non-nucleotide reversible antagonist of P2Y12R, which regulates platelet activation and thrombus formation.

Biological Activity

the central role of the p2y12 receptor in platelet function makes it an attractive target for the development of novel antiplatelet therapies. azd1283 is found to be a potent, selective and reversible antagonist of the p2y12 receptor.

in vitro

it was observed that the benzylic azd1283 and its analogue 13 were both potent in the higher order residual platelet count assay in which the two tested 5-chlorothienyls showed low (ic50 >22 μm) potency [1].

in vivo

in a modified folts model in dog, both azd1283 and its analogue 13 could dose-dependently induce increases in blood flow and inhibition of adp-induced platelet aggregation with antithrombotic ed50 values of 3.0 and 10.0 μg/kg/min, respectively. the dose that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for azd1283 and 13, respectively [2].

IC 50

0.011, 0.025 and 3.2 μm for binding, gtpγs and residual platelet count (rpc), respectively

storage

Store at -20°C

References

[1] bach p, antonsson t, bylund r, björkman ja, österlund k, giordanetto f, van giezen jj, andersen sm, zachrisson h, zetterberg f. lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the p2y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug azd1283. j med chem. 2013;56(17):7015-24.

AZD1283 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD1283 Suppliers

China 68 United Kingdom 1 United States 12 Global 81

MedChemexpress LLC

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MedChemExpress

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View Lastest Price from AZD1283 manufacturers

Career Henan Chemical Co

Product: AZD1283 919351-41-0
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

919351-41-0, AZD1283Related Search:

ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate AZD1283

ETHYL 6-(4-{[(BENZYLSULFONYL)AMINO]CARBONYL}PIPERIDIN-1-YL)-5-CYANO-2-METHYLNICOTINATE

AZD1283 , CID23649325

AZD1283

6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester

CS-1176

Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate

AZD-1283;AZD 1283

AZD1283, >98%

3-Pyridinecarboxylic acid, 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-, ethyl ester

P2Y Receptor,AZD-1283,thromboembolic,antiplatelet aggregation,AZD1283,inhibit,Inhibitor,antithrombotic,AZD 1283

ethyl 6-[4-(benzylsulfonylcarbamoyl)-1-piperidyl]-5-cyano-2-methyl-pyridine-3-carboxylate

Ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate

AZD1283, 10 mM in DMSO

919351-41-0