Btk Kinase inhibitor

ChemicalBook > CAS DataBase List > Btk Kinase inhibitor

Product Name: Btk Kinase inhibitor
CAS No.: 1351636-18-4
Chemical Name: Btk Kinase inhibitor
Synonyms: ONO-BKT;ONO BTK;Tirabrutinib;TIRABRUTINIB;GS-4059;Btk Kinase inhibitor;ONO-4059(Tirabrutinib);Tirabrutinib free base;Isoleucine Impurity 18;Tirabrutinib (ONO-4059);ONO-4059;ONO 4059;ONO4059
CBNumber: CB02716154
Molecular Formula: C25H22N6O3
Formula Weight: 454.48
MOL File: 1351636-18-4.mol

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Btk Kinase inhibitor Property

Boiling point:: 672.0±65.0 °C(Predicted)
Density: 1.412±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:65.0(Max Conc. mg/mL);143.02(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.66(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);66.01(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.2(Max Conc. mM)
form: A crystalline solid
pka: 3.16±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5676
Product name: Tirabrutinib
Purity: 99.31%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5676
Product name: Tirabrutinib
Purity: 99.31%
Packaging: 10mg
Price: $90
Updated: 2021/12/16

Activate Scientific

Product number: AS117581
Product name: ONO-4059
Purity: 98+%
Packaging: 1mg
Price: $94
Updated: 2021/12/16

ChemScene

Product number: CS-5676
Product name: Tirabrutinib
Purity: 99.31%
Packaging: 50mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: 2840DM
Product name: Tirabrutinib
Packaging: 2mg
Price: $309
Updated: 2021/12/16

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Btk Kinase inhibitor Chemical Properties,Usage,Production

Description

Btk Kinase inhibitor is highly potent and selective orally administered, small molecule, and also named tirabrutinib, Brutons tyrosine kinase (BTK) inhibitor being developed by Ono pharmaceutical and its licensee Gilead Sciences for the treatment of autoimmune disorders and haematological malignancies.

brand name

Velexbru^TM

Biological Functions

In March 2020, tirabrutinib was approved in Japan to treat primary central nervous system lymphoma (PCNSL). Tirabrutinib shows excellent selectivity against all kinases with cysteines in the ATP-binding site corresponding to Cys481 in BTK with the exception of BMX, TXK, and TEC? However, it displays weaker BTK inhibition than ibrutinib (IC50 = 6.8 nM vs. 0.47 nM).

General Description

Class: non-receptor tyrosine kinase
Treatment: PCNSL
Elimination half-life = 6.5–8 h
Protein binding = 91%

Mechanism of action

The selective inhibition of cell growth by Btk Kinase inhibitor was due to blocking of BTK-mediated signaling through AKT and cellular protein kinase D. It can inhibit autophosphorylation of the BTK at the Tyr223 position through the ERK, AKT and PKD signaling pathways.

Side effects

Adverse effects of the Btk Kinase inhibitor that occurred in some patients were rash, vomiting, neutropenia, arthralgia, and malaise, and drug-related Grade 3–4 Adverse effects were neutropenia, leukopenia, anemia, hypophosphatemia, PT-INR increased, pneumonitis, and acute myeloid leukemia. in prior Japanese studies, rash, hematologic adverse effects, erythema multiforme, and constipation were frequent adverse effects in a Phase I/II study of some patients with PCNSL, and rash, hematologic adverse effects, and stomatitis were the most common adverse effects in a Phase II study of some patients with WM.

target

BTK

Btk Kinase inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Btk Kinase inhibitor manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO-4059 1351636-18-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO-4059 1351636-18-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2022-08-05

Qiuxian Baitai New Material Co., LTD

Product: Tirabrutinib 1351636-18-4
Price: US $1.20/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-11-08

1351636-18-4, Btk Kinase inhibitorRelated Search:

ONO-4059 (hydrochloride)

Btk Kinase inhibitor

ONO BTK

ONO-4059(GS-4059,Tirabrutinib) free base

ONO-BKT

6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one

Tirabrutinib (ONO-4059)

ONO-4059;ONO 4059;ONO4059

6-amino-9-[(3R)-1-(but-2-ynoyl)pyrrolidin-3-yl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one

ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; TIRABRUTINIB

TIRABRUTINIB;GS-4059

Tirabrutinib

8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-

ONO-4059(Tirabrutinib)

Tirabrutinib free base

ONO4059-Analog(BTK inhibitor)

Isoleucine Impurity 18

1351636-18-4