ONO-4059 (hydrochloride)
- Product Name
- ONO-4059 (hydrochloride)
- CAS No.
- 1439901-97-9
- Chemical Name
- ONO-4059 (hydrochloride)
- Synonyms
- ON 0459;ON-0459;ONO-WG-307;ONO-4059 HCl;ON 0459;ON-0459;Tirabrutinib HCl;ONO-4059(HCl salt);ONO-4059 (GS-4059);GS-4059 (hydrochloride);ONO-4059 (hydrochloride)
- CBNumber
- CB93126702
- Molecular Formula
- C25H23ClN6O3
- Formula Weight
- 490.95
- MOL File
- 1439901-97-9.mol
ONO-4059 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- form
- A crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-5637
- Product name
- Tirabrutinib(hydrochloride)
- Purity
- 98.80%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-5637
- Product name
- Tirabrutinib(hydrochloride)
- Purity
- 98.80%
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-5637
- Product name
- Tirabrutinib(hydrochloride)
- Purity
- 98.80%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-5637
- Product name
- Tirabrutinib(hydrochloride)
- Purity
- 98.80%
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-5637
- Product name
- Tirabrutinib(hydrochloride)
- Purity
- 98.80%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
ONO-4059 (hydrochloride) Chemical Properties,Usage,Production
Uses
ONO-4059 hydrochloride is a potent orally active BTK (Bruton's tyrosine kinase) inhibitor, IC50: 2.2nM.It is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration,it covalently binds to BTK within B cells,thereby preventing B-cell receptor signaling and impeding B-cell development.
Biological Activity
Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with IC50 of 2.2 nM.
in vitro
Compared with Lck, Fyn, LynA, ONO-4059 is more selective for BTK, and only inhibits anti-IgM-induced B cell activation in a concentration-dependent manner, but not anti-CD3/CD28-induced Activation of human PBMCs to T lymphocytes. ONO/GS-4059 inhibited cell proliferation in some malignant B cells, but also in the nanomolar concentration range, induced the classical apoptotic response of TMD8 cells.
in vivo
In the CIA mouse model, ONO-4059 exerted its curative effect by inhibiting the production of inflammatory chemokines and cytokines such as IL-6, IL-8, TNFalpha, etc. in monocytes, accompanied by cartilage erosion, bone damage, vascular Recession of nebula formation. In preclinical animal models and clinical CLL and NHL patients, ONO-4059 has antitumor activity, good safety and long-lasting efficacy.
target
Target | Value |
BTK | 2.2 nM |
ONO-4059 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
ONO-4059 (hydrochloride) Suppliers
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View Lastest Price from ONO-4059 (hydrochloride) manufacturers
- Product
- ONO4059 hydrochloride 1439901-97-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- ONO4059 hydrochloride 1439901-97-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-11-26
- Product
- ONO4059 hydrochloride 1439901-97-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-11-26