ChemicalBook > CAS DataBase List > (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

Product Name
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
CAS No.
857629-79-9
Chemical Name
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Synonyms
Entacapone impurity D;(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-;Entacapone Impurity 4（Entacapone EP Impurity A）;Entacapone Impurity 4（Entacapone EP Impurity D）;Entacapone Impurity 20(Entacapone EP Impurity D);(E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylacrylamide;(E)-N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide;(E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide;(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide;(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
CBNumber
CB02717595
Molecular Formula
C16H19N3O5
Formula Weight
333.34
MOL File
857629-79-9.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C956045
Product name
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Packaging
250mg
Price
$840
Updated
2021/12/16
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(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Chemical Properties,Usage,Production

Uses

(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.

Definition

ChEBI: 3-O-ethylentacapone is a C-nitro compound that is entacapone in which the phenolic hydroxy group that is meta to the nitro group has been converted into the corresponding ethyl ether. It is a monocarboxylic acid amide, a nitrile, an aromatic ether and a member of 2-nitrophenols. It is functionally related to a 5-nitrovanillin and an entacapone.

(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Suppliers

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857629-79-9, (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamideRelated Search:

(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Entacapone EP IMpurity I TYRPHOSTIN AG 1290 Entacapone EP IMpurity B Sodium cyanoborohydride Entacapone EP Impurity G Entacapone Impurity 10 Entacapone Impurity 4 6-Methoxy-2,4-dinitrophenol Entacapone 3-b-D-Glucuronide Entacapone Impurity 13 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N,N-diethyl-, (2E)- (E/Z)-3-O-Methyl Entacapone 3-Nitro-4,5-dihydroxybenzaldehyde CIS-ENTACAPONE (E)-3-O-Methyl Entacapone Entacapone 3,5-DINITROCATECHOL

  • (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
  • Entacapone impurity D
  • Entacapone Impurity 20(Entacapone EP Impurity D)
  • Imp. D (EP):(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • Entacapone Impurity 4（Entacapone EP Impurity D）
  • (E)-N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide
  • (E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-
  • 2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
  • (E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylacrylamide
  • Entacapone Impurity 4（Entacapone EP Impurity A）
  • (E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylacrylamide (Entacapone Impurity)
  • (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • 857629-79-9