(3-ForMyl-phenyl)-acetic acid
- Product Name
- (3-ForMyl-phenyl)-acetic acid
- CAS No.
- 34956-29-1
- Chemical Name
- (3-ForMyl-phenyl)-acetic acid
- Synonyms
- Pratraxa impurity 4;3-formylbenzeneacetic acid;Benzeneacetic acid, 3-formyl-;2-(3-Formylphenyl)acetic acid;(3-ForMyl-phenyl)-acetic acid
- CBNumber
- CB02719933
- Molecular Formula
- C9H8O3
- Formula Weight
- 164.16
- MOL File
- 34956-29-1.mol
(3-ForMyl-phenyl)-acetic acid Property
- Melting point:
- 92-94 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
- Boiling point:
- 340.0±25.0 °C(Predicted)
- Density
- 1.277±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 4.19±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6431CV
- Product name
- 2-(3-Formylphenyl)aceticacid
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- A209963
- Product name
- 2-(3-Formylphenyl)aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $191
- Updated
- 2021/12/16
- Product number
- 34956291
- Product name
- 2-(3-Formylphenyl)aceticacid
- Packaging
- 250mg
- Price
- $210.12
- Updated
- 2021/12/16
- Product number
- CM183634
- Product name
- 2-(3-formylphenyl)aceticacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- CD12080406
- Product name
- 2-(3-Formylphenyl)aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $505
- Updated
- 2021/12/16
(3-ForMyl-phenyl)-acetic acid Chemical Properties,Usage,Production
Synthesis
621-36-3
34956-29-1
General procedure for the synthesis of 3-formylphenylacetic acid from 3-methylphenylacetic acid: N-bromosuccinimide (2.37 g, 13.32 mmol) was added to a chloroform (30 mL) solution of 2-(m-tolyl)acetic acid. The reaction mixture was heated to reflux for 8 hours, followed by removal of the solvent under vacuum. The residue was dissolved in a solvent mixture of ethanol (30 mL) and water (30 mL) and hexamethylenetetramine (5 g, 35.7 mmol) was added. The mixture was heated to reflux and maintained for 4 hours. Under reflux conditions, concentrated hydrochloric acid (5.9 mL) was slowly added. Continue heating to reflux for 30 minutes, then cool to room temperature. Water (30 mL) and dichloromethane (30 mL) were added and the organic phase was separated and filtered through hydrophobic glassine. The solvent was removed under vacuum. The residue was dissolved in saturated aqueous sodium bicarbonate and washed with dichloromethane (2 x 15 mL). The aqueous phase was acidified with aqueous 2M hydrochloric acid to pH < 2. The acidified aqueous phase was extracted with dichloromethane (2 x 15 mL), the organic phases were combined and filtered through a hydrophobic glass. The solvent was removed in vacuo to afford 3-formylphenylacetic acid as an off-white solid (1.35 g, 62% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 10.01 (s, 1H), 7.84-7.79 (m, 2H), 7.60-7.48 (m, 2H), 3.75 (s, 2H).LCMS (Method 1): [MH+] = 165, retention time 2.77 min.
References
[1] Patent: WO2014/86849, 2014, A1. Location in patent: Page/Page column 82
[2] Patent: US2014/155428, 2014, A1. Location in patent: Paragraph 0472; 0473
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8757 - 8770
[4] Patent: WO2018/69532, 2018, A1
(3-ForMyl-phenyl)-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (3-ForMyl-phenyl)-acetic acid manufacturers
- Product
- (3-ForMyl-phenyl)-acetic acid 34956-29-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-08
- Product
- (3-ForMyl-phenyl)-acetic acid 34956-29-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2020-01-06