(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

Product Name: (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
CAS No.: 1234563-16-6
Chemical Name: (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
Synonyms: AN3365;CS-2419;GSK-052;AN3365HCL;AN3365 HCl salt;AN 3365;AN-3365;Epetraborole HCl;AN3365 GSK225052;AN3365(GSK2251052);AN3365 (Epetraborole)
CBNumber: CB02722139
Molecular Formula: C11H16BNO4
Formula Weight: 237.06004
MOL File: 1234563-16-6.mol

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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Property

storage temp.: Store at -20°C
solubility: DMSO:200.0(Max Conc. mg/mL);731.21(Max Conc. mM)
Water:28.0(Max Conc. mg/mL);102.37(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20572
Product name: AN3365 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20572
Product name: AN3365 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 20572
Product name: AN3365 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 20572
Product name: AN3365 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

ApexBio Technology

Product number: C5068
Product name: AN3365(hydrochloride)
Packaging: 25mg
Price: $608
Updated: 2021/12/16

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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Chemical Properties,Usage,Production

Uses

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].

References

[1] Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. DOI:10.1128/AAC.02580-12
[2] O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. DOI:10.1128/AAC.03774-14
[3] Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52. DOI:10.1111/j.1749-6632.2011.06323.x

(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Suppliers

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Musechem

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View Lastest Price from (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol manufacturers

Career Henan Chemical Co

Product: Epetraborole hydrochloride 1234563-16-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1234563-16-6, (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-olRelated Search:

LITHIUM DIMETHYLAMIDE Hexamethyldisilazane 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine URMC-099 CC-223 N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

AN3365

Epetraborole HCl

Epetraborole (hydrochloride)

AN 3365;AN-3365;GSK2251052;GSK 2251052;GSK-2251052

3-[[(3S)-3-(Aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol hydrochloride (1:1)

AN3365HCL

AN3365 (hydrochloride)

AN3365(GSK2251052)

AN3365 (Epetraborole)

AN3365 HCl salt

CS-2419

AN 3365;AN-3365

(S)-3-(aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

GSK2251052 hydrochloride

Epetraborole(GSK2251052) hydrochloride

1-Propanol,3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-,hydrochloride(1:1)

Bacterial,GSK2251052,Epetraborole,GSK-2251052,Epetraborole hydrochloride,GSK 2251052,inhibit,Inhibitor

(S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol HCl

AN3365 GSK225052

GSK-052

1234563-16-6

C11H16BNO4HCl