4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

Product Name: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
CAS No.: 1533519-84-4
Chemical Name: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Synonyms: LES10;Lesinurad INT3;LESINURAD intermdiate;Lesinurad intermediate;4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-1H-1;1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)-;4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol;4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol
CBNumber: CB02725589
Molecular Formula: C15H13N3S
Formula Weight: 267.35
MOL File: 1533519-84-4.mol

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Property

Boiling point:: 435.2±38.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.89±0.20(Predicted)
Appearance: White to off-white Powder
InChI: InChI=1S/C15H13N3S/c19-15-17-16-9-18(15)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-10H,5-6H2,(H,17,19)
InChIKey: UFYFJMMSOUURSF-UHFFFAOYSA-N
SMILES: N1=CN(C2=C3C(C=CC=C3)=C(C3CC3)C=C2)C(=S)N1
CAS DataBase Reference: 1533519-84-4

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C989518
Product name: 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Packaging: 10g
Price: $160
Updated: 2021/12/16

TRC

Product number: C989518
Product name: 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Packaging: 25g
Price: $340
Updated: 2021/12/16

Ark Pharm

Product number: P000123218
Product name: 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Purity: 97%
Packaging: 10g
Price: $155
Updated: 2021/12/16

Ark Pharm

Product number: P000123218
Product name: 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Purity: 97%
Packaging: 25g
Price: $247
Updated: 2021/12/16

AK Scientific

Product number: 0002AP
Product name: 4-(4-Cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-thiol
Packaging: 25g
Price: $520
Updated: 2021/12/16

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Chemical Properties,Usage,Production

Chemical Properties

Off white powder

Uses

4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is a reagent used in the discovery of Lesinurad, a HEK293 cell-based inhibitor.

Synthesis

1533519-86-6

1533519-84-4

Example 5. Preparation of 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiols To a round-bottomed flask was added N-(4-cyclopropyl-1-naphthalenyl)-2-formylhydrazine thiocarboxamide (64.0 g, 225 mmol), N,N-dimethylformamide (300 mL), and 1 mol/L aqueous sodium hydroxide solution (225 mL) to form a mixture. After stirring, the mixture was heated to 30 °C and kept for 16 hours. After the reaction was completed, the mixture was cooled to room temperature (about 20°C). Subsequently, 1 mol/L hydrochloric acid (about 200 mL) was slowly added to the mixture until the pH of the mixture was about 6.0, and then water (about 500 mL) was added. The mixture was stirred for 15 minutes and then filtered. The filter cake was washed with water and the product was dried under vacuum at 50 °C for 5 h to give 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol as a gray-green solid, 54.0 g in 90% yield. LC-MS: m/z (ESI): 268 (M + H)+. 1H NMR (400 MHz, acetone-d6): δ 8.57 (d, J = 8.0 Hz, 1H), 8.37 (s, 1H), 7.67 (m, 1H), 7.60 (m, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 7.43 (d, J = 8.0 Hz, 1H), 2.50 (m, 1H), 1.16 (m, 2H), 0.84 (m, 2H).

References

[1] Patent: WO2014/198241, 2014, A1. Location in patent: Paragraph 069-070
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0337

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Suppliers

China 175 India 2 United Kingdom 2 United States 3 Global 182

Shanghai Feibo Chemical Technology Co., Ltd

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Synches Co., Ltd.

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View Lastest Price from 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

1533519-84-4, 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thioneRelated Search:

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

lesinurad int.4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

Sodium 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate

4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol

LES10

Rexinad Intermediate: 4- (1-cyclopropylnaphthalen-4-yl) -4H-1,2,4-triazole-3-thiol

Lesinurad INT3

4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (for Lesinurad)

4-(4-Cyclopropylnaphthalen-1-yl)-1H-1

4-triazole-5(4H)-thione

Lesinurad intermediate

LESINURAD intermdiate

4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol

4-(4-cyclopropylnaphthalene - 1-yl)-4H-1,2, 4-triazol-3-mercapta

4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione

4- (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5 (4H) -thioketone

4-(4-Cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thi...

1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)-

4-(4-cyclopropyl-1-naphthyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

1533519-84-4