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lesinurad int

Product Name
lesinurad int
CAS No.
1533519-85-5
Chemical Name
lesinurad int
Synonyms
lesinurad int;LSEINURAD INT;Lesinurad INT4;Lesinurad internate 4;Intermediate of lesinurad;4-triazol-3-yl]thio]acetate;Pentanedioicacid,5-oxo-,dimethylester;Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1;Acetic acid, 2-((4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-t...;2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl]
CBNumber
CB32725616
Molecular Formula
C18H17N3O2S
Formula Weight
339.41
MOL File
1533519-85-5.mol
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lesinurad int Property

Boiling point:
546.4±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
0.56±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm
Product number
P000123219
Product name
Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
Purity
97%
Packaging
100mg
Price
$15
Updated
2021/12/16
Ark Pharm
Product number
P000123219
Product name
Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
Purity
97%
Packaging
250mg
Price
$22
Updated
2021/12/16
AK Scientific
Product number
0003AP
Product name
Methyl{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetate
Packaging
25mg
Price
$49
Updated
2021/12/16
Ark Pharm
Product number
P000123219
Product name
Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
Purity
97%
Packaging
1g
Price
$53
Updated
2021/12/16
AK Scientific
Product number
0003AP
Product name
Methyl{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetate
Packaging
100mg
Price
$117
Updated
2021/12/16
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lesinurad int Chemical Properties,Usage,Production

Synthesis

1533519-84-4

96-32-2

1533519-85-5

In a 100 mL three-necked round-bottomed flask equipped with a magnetic stirrer and thermometer, 25 mL of N,N-dimethylformamide (DMF) and intermediate (III) (2.67 g, 1-cyclopropyl-4-isothiocyanonaphthalene) were added. After stirring at room temperature until complete dissolution, potassium carbonate (1.45 g) and methyl bromoacetate (1.61 g) were added sequentially. The reaction temperature was controlled at 25°C. After the slow addition, the reaction was continued with stirring for 3 hours. Upon completion of the reaction, 50 mL of water was added to the reaction mixture for dilution, followed by extraction with ethyl acetate (50 mL × 3). The organic phases were combined and the ethyl acetate was removed by concentration using a rotary evaporator. To the concentrated residue, 50 mL of methanol was added and heated to reflux to dissolve the crystals, followed by slow cooling to room temperature for recrystallization. The crystals were collected by filtration and washed with a small amount of cold methanol and dried under vacuum to give 3.22 g of Intermediate (IV) (methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate) in 99.5% yield.

References

[1] Patent: CN105906576, 2016, A. Location in patent: Paragraph 0070; 0071; 0083; 0084
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0254-0262
[3] Patent: CN105399694, 2016, A. Location in patent: Paragraph 0085; 0086; 0087; 0088
[4] Patent: CN107098866, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082; 0083

lesinurad int Preparation Products And Raw materials

Raw materials

Preparation Products

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lesinurad int Suppliers

China 100 India 2 United Kingdom 1 United States 5 Global 108
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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025-58741518 13327700685
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+86-25-58744115
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sales@vcarepharmatech.com
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China
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Shanghai Feibo Chemical Technology Co., Ltd
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021-58955608,2250286 15921236618
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China
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Synches Co., Ltd.
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021-53292253
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biz@synches.com
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sales@joyouschem.com
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021-58170097
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info@topbiochem.com
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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
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21-33585366 13311639313
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+86-21-34979012
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sales@shyrchem.com
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China
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Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
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+86-28-85122536 85324413
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+86-28-85326443
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market@astatech.cn
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Shanghai SE Pharm Co., Ltd
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View Lastest Price from lesinurad int manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
lesinurad int 1533519-85-5
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-09-09
Henan Aochuang Chemical Co.,Ltd.
Product
lesinurad int 1533519-85-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Hebei Yanxi Chemical Co., Ltd.
Product
lesinurad int 1533519-85-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09

1533519-85-5, lesinurad intRelated Search:

Lesinurad Impurity 10 Lesinurad Impurity 4 1-cyclopropylnaphthalene Lesinurad Impurity J NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO- RDEA 594 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Lesinurad Impurity 29 Lesinurad Impurity 23 Lesinurad Impurity 5 Sodium Salt 3-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide Lesinurad Impurity 38 Lesinurad Impurity 32 (Mixture of Isomers) Lesinurad Impurity H Lesinurad Impurity 24 Lesinurad Impurity N Lesinurad Impurity 27

  • lesinurad int
  • Lesinurad INT4
  • 2-[[4- (4-cyclopropylnaphthalen-1-yl) -4H-1,2,4-triazol-3-yl] thio] methyl acetate
  • Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate
  • Acetic acid, 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester
  • Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate(for Lesinurad)
  • 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester
  • 4-triazol-3-yl]thio]acetate
  • Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1
  • Intermediate of lesinurad
  • 2-[[[4- (4-cyclopropyl-1-naphthalyl) -4H-1,2, 4-triazol-3-yl] thio] -methyl ester
  • LSEINURAD INT
  • Lesinurad internate 4
  • Acetic acid, 2-((4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-t...
  • 2-1[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-.methyl ester
  • Pentanedioicacid,5-oxo-,dimethylester
  • 2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl]
  • 2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl]thiol] acetate
  • 1533519-85-5