ChemicalBook > CAS DataBase List > 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

Product Name
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
CAS No.
1533519-84-4
Chemical Name
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Synonyms
LES10;Lesinurad INT3;LESINURAD intermdiate;Lesinurad intermediate;4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-1H-1;1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)-;4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol;4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol
CBNumber
CB02725589
Molecular Formula
C15H13N3S
Formula Weight
267.35
MOL File
1533519-84-4.mol
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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Property

Boiling point:
435.2±38.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
7.89±0.20(Predicted)
Appearance
White to off-white Powder
InChI
InChI=1S/C15H13N3S/c19-15-17-16-9-18(15)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-10H,5-6H2,(H,17,19)
InChIKey
UFYFJMMSOUURSF-UHFFFAOYSA-N
SMILES
N1=CN(C2=C3C(C=CC=C3)=C(C3CC3)C=C2)C(=S)N1
CAS DataBase Reference
1533519-84-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C989518
Product name
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Packaging
10g
Price
$160
Updated
2021/12/16
TRC
Product number
C989518
Product name
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Packaging
25g
Price
$340
Updated
2021/12/16
Ark Pharm
Product number
P000123218
Product name
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Purity
97%
Packaging
10g
Price
$155
Updated
2021/12/16
Ark Pharm
Product number
P000123218
Product name
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Purity
97%
Packaging
25g
Price
$247
Updated
2021/12/16
AK Scientific
Product number
0002AP
Product name
4-(4-Cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-thiol
Packaging
25g
Price
$520
Updated
2021/12/16
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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Chemical Properties,Usage,Production

Chemical Properties

Off white powder

Uses

4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is a reagent used in the discovery of Lesinurad, a HEK293 cell-based inhibitor.

Synthesis

1533519-86-6

1533519-84-4

Example 5. Preparation of 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiols To a round-bottomed flask was added N-(4-cyclopropyl-1-naphthalenyl)-2-formylhydrazine thiocarboxamide (64.0 g, 225 mmol), N,N-dimethylformamide (300 mL), and 1 mol/L aqueous sodium hydroxide solution (225 mL) to form a mixture. After stirring, the mixture was heated to 30 °C and kept for 16 hours. After the reaction was completed, the mixture was cooled to room temperature (about 20°C). Subsequently, 1 mol/L hydrochloric acid (about 200 mL) was slowly added to the mixture until the pH of the mixture was about 6.0, and then water (about 500 mL) was added. The mixture was stirred for 15 minutes and then filtered. The filter cake was washed with water and the product was dried under vacuum at 50 °C for 5 h to give 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol as a gray-green solid, 54.0 g in 90% yield. LC-MS: m/z (ESI): 268 (M + H)+. 1H NMR (400 MHz, acetone-d6): δ 8.57 (d, J = 8.0 Hz, 1H), 8.37 (s, 1H), 7.67 (m, 1H), 7.60 (m, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 7.43 (d, J = 8.0 Hz, 1H), 2.50 (m, 1H), 1.16 (m, 2H), 0.84 (m, 2H).

References

[1] Patent: WO2014/198241, 2014, A1. Location in patent: Paragraph 069-070
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0337

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Suppliers

China 175 India 2 United Kingdom 2 United States 3 Global 182
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
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United Kingdom
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Sinbond Industiral Co., Ltd.
Tel
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Email
cici1124@gmail.com
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View Lastest Price from 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Henan Aochuang Chemical Co.,Ltd.
Product
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Hebei Yanxi Chemical Co., Ltd.
Product
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08

1533519-84-4, 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thioneRelated Search:

Lesinurad Impurity B Lesinurad Impurity 5 Sodium Salt Lesinurad Impurity C1 Lesinurad Impurity 2 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Lesinurad Impurity 4 Lesinurad Impurity J Lesinurad Impurity 10 3-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Lesinurad Impurity 22 4-cyclopropylnaphthalen-1-aMine hydrochloride Lesinurad Impurity A Methyl 2-(5-broMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide Lesinurad Impurity N Lesinurad M4 Metabolite NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO- lesinurad int

  • 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
  • lesinurad int.4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
  • Sodium 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
  • 4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
  • LES10
  • Rexinad Intermediate: 4- (1-cyclopropylnaphthalen-4-yl) -4H-1,2,4-triazole-3-thiol
  • Lesinurad INT3
  • 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
  • 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (for Lesinurad)
  • 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1
  • 4-triazole-5(4H)-thione
  • Lesinurad intermediate
  • LESINURAD intermdiate
  • 4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol
  • 4-(4-cyclopropylnaphthalene - 1-yl)-4H-1,2, 4-triazol-3-mercapta
  • 4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione
  • 4- (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5 (4H) -thioketone
  • 4-(4-Cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
  • 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thi...
  • 1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)-
  • 4-(4-cyclopropyl-1-naphthyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
  • 1533519-84-4
  • 1533519-84-4