ChemicalBook > CAS DataBase List > KN-93 Phosphate

KN-93 Phosphate

Product Name: KN-93 Phosphate
CAS No.: 1188890-41-6
Chemical Name: KN-93 Phosphate
Synonyms: CS-1902;KN 93; KN93;KN-93PHOSPHATE;KN-93 phospate;(E)-KN-93 (phosphate);KN-93 phosphate, >=98%;KN 93 Phosphate (E-form);KN-93 Phosphate USP/EP/BP;KN-93 (water soluble), CaMK II inhibitor;(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate
CBNumber: CB02729653
Molecular Formula: C26H32ClN2O8PS
Formula Weight: 599.032641
MOL File: 1188890-41-6.mol

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KN-93 Phosphate Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMF:25.0(Max Conc. mg/mL);41.73(Max Conc. mM)
DMSO:76.67(Max Conc. mg/mL);127.98(Max Conc. mM)
Water:49.33(Max Conc. mg/mL);82.35(Max Conc. mM)
form: White to off-white solid.
color: White to off-white
Water Solubility: Soluble in water (10mM)
CAS DataBase Reference: 1188890-41-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21472
Product name: KN-93 (phosphate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21472
Product name: KN-93 (phosphate)
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 21472
Product name: KN-93 (phosphate)
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 21472
Product name: KN-93 (phosphate)
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 5215
Product name: KN93phosphate
Purity: ≥98%(HPLC)
Packaging: 1
Price: $141
Updated: 2021/12/16

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KN-93 Phosphate Chemical Properties,Usage,Production

Description

KN-93 (phosphate) is a potent and selective inhibitor of Ca²⁺/calmodulin-dependent kinase II (CaMKII) (K_i = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca²⁺/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca²⁺ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM). KN-93 can block voltage-gated potassium (K_v) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells.

Uses

KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

IC 50

CaMK IIα

storage

-20°C

References

[1] MARIKO SUMI . The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells[J]. Biochemical and biophysical research communications, 1991, 181 3: Pages 968-975. DOI: 10.1016/0006-291x(91)92031-e
[2] N. MAMIYA. Inhibition of Acid Secretion in Gastric Parietal Cells by the Ca2+/ Calmodulin-Dependent Protein Kinase II Inhibitor KN-93.[J]. Japanese journal of pharmacology, 1994, 10 2 1: 90. DOI: 10.1016/s0021-5198(19)50001-4
[3] SAMAN REZAZADEH D F Thomas W Claydon. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 317 1: 292-299. DOI: 10.1124/jpet.105.097618
[4] EMILY A OESTREICH. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.[J]. The Journal of Biological Chemistry, 2009, 284 3: 1514-1522. DOI: 10.1074/jbc.m806994200
[5] NICOLAS FLAMAND. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.[J]. Mobilities, 2009, 12 1: 306-313. DOI: 10.1074/jbc.m805593200
[6] C RIGANTI. Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression[J]. British Journal of Pharmacology, 2009, 156 7: 1054-1066. DOI: 10.1111/j.1476-5381.2009.00117.x

KN-93 Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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KN-93 Phosphate Suppliers

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1188890-41-6, KN-93 PhosphateRelated Search:

KN-62 Aprepitant 1,9-Pyrazoloanthrone PD 0332991 HCl Veliparib CHIR-99021

KN-93PHOSPHATE

Benzenesulfonamide, N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-, phosphate (1:1)

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4- methoxybenzenesulphonamide phosphate KN-93 Phosphate

KN-93 phosphate, >=98%

KN-93 phospate

N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1)

CS-1902

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate

KN 93; KN93

KN-93 Phosphate USP/EP/BP

(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate

(E)-KN-93 (phosphate)

KN 93 Phosphate (E-form)

N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monophosphate

KN-93 (water soluble), CaMK II inhibitor

1188890-41-6

C26H32ClN2O8PS

C26H29ClN2O4SH3O4P

C26H29ClN2O4SH3PO4

Inhibitors