HYPERFORIN

Product Name: HYPERFORIN
CAS No.: 11079-53-1
Chemical Name: HYPERFORIN
Synonyms: HYPERFORIN;HYPERFORIN MIX;HYPERFORIN MIX(P);HYPERFORIN USP/EP/BP;Hyperforin (solution in Ethanol);Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-;methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-;4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE;(1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
CBNumber: CB0273398
Molecular Formula: C35H52O4
Formula Weight: 536.78
MOL File: 11079-53-1.mol

More

Less

HYPERFORIN Property

Melting point:: 79-80℃
alpha: D18 +41° (in ethanol)
Boiling point:: 616.8±55.0 °C(Predicted)
Density: 1.010±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 9℃
storage temp.: -20°C
pka: 4.8 (50% aq ethanol)
form: solution
CAS DataBase Reference: 11079-53-1

More

Less

Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol
WGK Germany: 3
HS Code: 29144000
Hazardous Substances Data: 11079-53-1(Hazardous Substances Data)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5160
Product name: Hyperforin
Purity: ≥85%(HPLC)
Packaging: 250μg
Price: $280
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FH64889
Product name: Hyperforin
Packaging: 2mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH64889
Product name: Hyperforin
Packaging: 5mg
Price: $600
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH64889
Product name: Hyperforin
Packaging: 10mg
Price: $1000
Updated: 2021/12/16

AK Scientific

Product number: 9179BB
Product name: Hyperforin (dicyclohexylammonium) salt
Packaging: 10mg
Price: $1130
Updated: 2021/12/16

More

Less

HYPERFORIN Chemical Properties,Usage,Production

Uses

St. John’s wort is a widely consumed herbal preparation which has been claimed to have a number of medicinal properties. It contains a number of known lipid signalling mediators, including chlorogenic acid, hypericin, hyperforin, and I3,II8-biapigenin. Hyperforin exhibits two activities which may alter the action of other concurrent medications. It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC50 of about 10 μg/ml. Hyperforin is also a ligand for the steroid X receptor (SXR). Since one activity of this receptor is the induction of CYP450 expression, the exact nature of hyperforin’s drug-drug interactions must be evaluated on a case-by-case basis. However, these interactions certainly complicate its use as a human therapeutic.[Cayman Chemical]

Uses

Hyperforin may be used:

as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

Definition

ChEBI: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.

General Description

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

Biochem/physiol Actions

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

HYPERFORIN Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

HYPERFORIN Suppliers

China 61 Germany 3 India 1 Switzerland 1 United Kingdom 6 United States 17 Global 89

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4552
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Stanford Chemicals Company

Tel: +1 (949) 468-0555
Fax: +1 (949) 812-6690
Email: sales@stanfordchem.com
Country: United States
ProdList: 13
Advantage: 60

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

More

Less

View Lastest Price from HYPERFORIN manufacturers

Career Henan Chemical Co

Product: Hyperforin 11079-53-1
Price: US $9.80/KG
Min. Order: 1KG
Purity: ＞98%HPLC
Supply Ability: 20 tons
Release date: 2020-02-06

11079-53-1, HYPERFORINRelated Search:

2,6-DIMETHYL-3,5-HEPTANEDIONE 2-Isobutyrylcyclohexanone 3-N-PENTYL-2,4-PENTANEDIONE HYPERFORIN 2-ACETYLCYCLOHEXANONE 2,4,4-TRIMETHYL-2-CYCLOHEXEN-1-ONE 2,2,6,6-TETRAMETHYLCYCLOHEXANONE TETRAISOBUTYLENE 3-METHYLCYCLOOCTENE 3-METHYL-NONANE-2,4-DIONE 3-ethyl-3,7-dimethyloct-6-enal NONANE-4,6-DIONE 1-METHYL-1-CYCLOOCTENE 4,4-DIPROPYLCYCLOHEX-2-ENONE HYPERFORIN HYPERFORIN REFERENCE MATERIAL(REAGENT / STANDARD GRADE) HYPERFORIN REFERENCE MATERIAL(SH) HYPERFORIN DICYCLOHEXYLAMMONIUM SALT

Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-

methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-

4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE

HYPERFORIN

(1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione

HYPERFORIN MIX(P)

Hyperforin (solution in Ethanol)

Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-

HYPERFORIN USP/EP/BP

HYPERFORIN MIX

11079-53-1

C35H52O4

BioChemical

Anti-Proliferative Agents

Antitumor Agents

Cancer Research

AntidepressantsNutrition Research

Anti-Proliferative AgentsNeurobiology

Antitumor Agents

Biochemicals Found in Plants

Cancer Research

Isoprenoid/terpenoid

Pharmacologicals

Miscellaneous Natural Products