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HYPERFORIN

Product Name
HYPERFORIN
CAS No.
11079-53-1
Chemical Name
HYPERFORIN
Synonyms
HYPERFORIN;HYPERFORIN MIX(P);HYPERFORIN USP/EP/BP;Hyperforin (solution in Ethanol);Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-;methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-;4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE;(1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
CBNumber
CB0273398
Molecular Formula
C35H52O4
Formula Weight
536.78
MOL File
11079-53-1.mol
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HYPERFORIN Property

Melting point:
79-80℃
alpha 
D18 +41° (in ethanol)
Boiling point:
616.8±55.0 °C(Predicted)
Density 
1.010±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
9℃
storage temp. 
-20°C
pka
4.8 (50% aq ethanol)
form 
solution
CAS DataBase Reference
11079-53-1
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
3
HS Code 
29144000
Hazardous Substances Data
11079-53-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5160
Product name
Hyperforin
Purity
≥85%(HPLC)
Packaging
250μg
Price
$280
Updated
2024/03/01
Biosynth Carbosynth
Product number
FH64889
Product name
Hyperforin
Packaging
2mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FH64889
Product name
Hyperforin
Packaging
5mg
Price
$600
Updated
2021/12/16
Biosynth Carbosynth
Product number
FH64889
Product name
Hyperforin
Packaging
10mg
Price
$1000
Updated
2021/12/16
AK Scientific
Product number
9179BB
Product name
Hyperforin (dicyclohexylammonium) salt
Packaging
10mg
Price
$1130
Updated
2021/12/16
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HYPERFORIN Chemical Properties,Usage,Production

Uses

St. John’s wort is a widely consumed herbal preparation which has been claimed to have a number of medicinal properties. It contains a number of known lipid signalling mediators, including chlorogenic acid, hypericin, hyperforin, and I3,II8-biapigenin. Hyperforin exhibits two activities which may alter the action of other concurrent medications. It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC50 of about 10 μg/ml. Hyperforin is also a ligand for the steroid X receptor (SXR). Since one activity of this receptor is the induction of CYP450 expression, the exact nature of hyperforin’s drug-drug interactions must be evaluated on a case-by-case basis. However, these interactions certainly complicate its use as a human therapeutic.[Cayman Chemical]

Uses

Hyperforin may be used:

  • as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
  • to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
  • as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

Definition

ChEBI: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.

General Description

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

Biochem/physiol Actions

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

HYPERFORIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HYPERFORIN Suppliers

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View Lastest Price from HYPERFORIN manufacturers

Career Henan Chemical Co
Product
Hyperforin 11079-53-1
Price
US $9.80/KG
Min. Order
1KG
Purity
＞98%HPLC
Supply Ability
20 tons
Release date
2020-02-06

11079-53-1, HYPERFORINRelated Search:

2,6-DIMETHYL-3,5-HEPTANEDIONE 2-Isobutyrylcyclohexanone 3-N-PENTYL-2,4-PENTANEDIONE HYPERFORIN 2-ACETYLCYCLOHEXANONE 2,4,4-TRIMETHYL-2-CYCLOHEXEN-1-ONE 2,2,6,6-TETRAMETHYLCYCLOHEXANONE TETRAISOBUTYLENE 3-METHYLCYCLOOCTENE 3-METHYL-NONANE-2,4-DIONE 3-ethyl-3,7-dimethyloct-6-enal NONANE-4,6-DIONE 1-METHYL-1-CYCLOOCTENE 4,4-DIPROPYLCYCLOHEX-2-ENONE HYPERFORIN HYPERFORIN REFERENCE MATERIAL(REAGENT / STANDARD GRADE) HYPERFORIN REFERENCE MATERIAL(SH) HYPERFORIN DICYCLOHEXYLAMMONIUM SALT

  • Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-
  • methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
  • 4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE
  • HYPERFORIN
  • (1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione
  • HYPERFORIN MIX(P)
  • Hyperforin (solution in Ethanol)
  • Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
  • HYPERFORIN USP/EP/BP
  • 11079-53-1
  • C35H52O4
  • BioChemical
  • Anti-Proliferative Agents
  • Antitumor Agents
  • Cancer Research
  • AntidepressantsNutrition Research
  • Anti-Proliferative AgentsNeurobiology
  • Antitumor Agents
  • Biochemicals Found in Plants
  • Cancer Research
  • Isoprenoid/terpenoid
  • Pharmacologicals
  • Miscellaneous Natural Products