ChemicalBook > CAS DataBase List > LDC1267
LDC1267
- Product Name
- LDC1267
- CAS No.
- 1361030-48-9
- Chemical Name
- LDC1267
- Synonyms
- CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-
- CBNumber
- CB02734808
- Molecular Formula
- C30H26F2N4O5
- Formula Weight
- 560.55
- MOL File
- 1361030-48-9.mol
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LDC1267 Property
- Boiling point:
- 628.4±55.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
- form
- solid
- pka
- 9.36±0.70(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29459
- Product name
- LDC-1267
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29459
- Product name
- LDC-1267
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29459
- Product name
- LDC-1267
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29459
- Product name
- LDC-1267
- Packaging
- 10mg
- Price
- $239
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-3603
- Product name
- LDC1267
- Purity
- 99.39%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
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LDC1267 Chemical Properties,Usage,Production
Biological Activity
LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
in vitro
LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.
in vivo
In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
target
| Target | Value |
| Mer (Cell-free assay) | <5 nM |
| Tyro3 (Cell-free assay) | 8 nM |
| Axl (Cell-free assay) | 29 nM |
LDC1267 Preparation Products And Raw materials
Raw materials
Preparation Products
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LDC1267 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58