UNC2250

Product Name: UNC2250
CAS No.: 1493694-70-4
Chemical Name: UNC2250
Synonyms: CS-1346;UNC2250;UNC2250(UNC 2250);UNC2250 USP/EP/BP;trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250
CBNumber: CB82677545
Molecular Formula: C24H36N6O2
Formula Weight: 440.58
MOL File: 1493694-70-4.mol

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UNC2250 Property

Melting point:: 207-210oC
Boiling point:: 657.4±65.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 15.02±0.40(Predicted)
color: Pale Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3620
Product name: UNC2250
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $79
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML3620
Product name: UNC2250
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $319
Updated: 2023/06/20

Cayman Chemical

Product number: 17703
Product name: UNC2250
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17703
Product name: UNC2250
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17703
Product name: UNC2250
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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UNC2250 Chemical Properties,Usage,Production

Description

Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC₅₀ value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.

Uses

(1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol inhibits steady-state phosphorylation of endogenous Mer and blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. (1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol also decreases colony-forming potential in rhabdoid and NSCLC tumor cells.

References

[1] zhang w, zhang d, stashko m a, et al. pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new mer kinase inhibitors. journal of medicinal chemistry, 2013, 56(23): 9683-9692.

UNC2250 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2250 Suppliers

China 69 India 1 The Netherlands 1 United Kingdom 1 United States 9 Global 81

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Dalian Meilun Biotech Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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TargetMol Chemicals Inc.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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ChemStrong Scientific Co.,Ltd

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Shanghai Qinghang Chemical Co. Ltd.

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AdooQ Bioscience CHINA

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LETOPHARM LIMITED

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1493694-70-4, UNC2250Related Search:

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(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol

UNC2250

trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol

CS-1346

trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250

UNC2250(UNC 2250)

4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol

Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-

UNC2250 USP/EP/BP

trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol

1493694-70-4

C24H36N6O2

Inhibitors