UNC0379

Product Name: UNC0379
CAS No.: 1620401-82-2
Chemical Name: UNC0379
Synonyms: UNC03;CS-1767;UNC0379;UNC0379, >=98%;UNC0379 USP/EP/BP;UNC 0379; UNC-0379;UNC0379, UNC-0379, UNC 0379;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine;4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
CBNumber: CB92715675
Molecular Formula: C23H35N5O2
Formula Weight: 413.56
MOL File: 1620401-82-2.mol

More

Less

UNC0379 Property

Boiling point:: 606.3±65.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (up to 30 mg/ml)
pka: 10.54±0.20(Predicted)
form: solid
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 25mg
Price: $298
Updated: 2024/03/01

Axon Medchem

Product number: Axon2418
Product name: UNC0379
Purity: 98%
Packaging: 10mg
Price: $137.5
Updated: 2021/12/16

ApexBio Technology

Product number: B8009
Product name: UNC0379
Packaging: 5mg
Price: $158
Updated: 2021/12/16

More

Less

UNC0379 Chemical Properties,Usage,Production

Description

UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2

References

1) Ma et al. (2014), Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8; J. Med. Chem. 57 6822 2) Veschi et al. (2017), Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma; Cancer Cell 31 50

UNC0379 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

UNC0379 Suppliers

China 83 France 1 India 1 The Netherlands 1 United Kingdom 1 United States 14 Global 101

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 905
Advantage: 64

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1874
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

YouCoChem (Beijing) Chemical Technology Co., Ltd.

Tel: 18800159827
Email: youcochem@163.com
Country: China
ProdList: 161
Advantage: 50

More

Less

View Lastest Price from UNC0379 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: UNC0379 1620401-82-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

1620401-82-2, UNC0379Related Search:

UNC 1999 UNC3230 UNC0321 UNC2881 Y27632 (hydrochloride) TG101209 GO 6983 Paclitaxel GDC-0152 SGC0946 UNC3866 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 UNC0646 NUC-7738

UNC0379

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379

UNC0379, >=98%

UNC03

6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine

UNC0379, UNC-0379, UNC 0379

UNC 0379; UNC-0379

CS-1767

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

UNC0379 USP/EP/BP

1620401-82-2

C23H35N5O2

Inhibitors