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UNC569

Product Name
UNC569
CAS No.
1350547-65-7
Chemical Name
UNC569
Synonyms
UNC569;CS-2399;UNC-569;UNC 569;UNC569, 10 mM in DMSO;1-[(4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-6-amine;1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine;1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-;N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine;anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl
CBNumber
CB72630103
Molecular Formula
C22H29FN6
Formula Weight
396.5
MOL File
1350547-65-7.mol
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UNC569 Property

storage temp. 
Store at -20°C
solubility 
DMF: 2.5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: 2 mg/ml
form 
A crystalline solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22966
Product name
UNC569
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22966
Product name
UNC569
Purity
≥98%
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
22966
Product name
UNC569
Purity
≥98%
Packaging
10mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
22966
Product name
UNC569
Purity
≥98%
Packaging
25mg
Price
$573
Updated
2024/03/01
AK Scientific
Product number
6662DK
Product name
1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine
Packaging
25mg
Price
$735
Updated
2021/12/16
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UNC569 Chemical Properties,Usage,Production

Uses

UNC 569 induces morphological changes in pigment epithelia and photoreceptor cells in retina through MerTK inhibition in mice. A specific MerTK inhibitor.

in vivo

The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[1].
Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 μM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[2].

IC 50

Axl; Tyro3; Mer

UNC569 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC569 Suppliers

China 40 United States 4 Global 44
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1377
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9964
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

1350547-65-7, UNC569Related Search:

UNC0321 UNC 1079 UNC 0224 UNC3866 UNC0379 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC0646 NUC-7738 UNC2025 UNC0638 UNC-0642 UNC 0631 UNC 1999

  • UNC569
  • 1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-
  • CS-2399
  • UNC-569;UNC 569
  • anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl
  • 1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
  • N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine
  • UNC569, 10 mM in DMSO
  • 1-[(4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-6-amine
  • 1350547-65-7
  • C22H29FN6