UNC569

ChemicalBook > CAS DataBase List > UNC569

Product Name: UNC569
CAS No.: 1350547-65-7
Chemical Name: UNC569
Synonyms: UNC569;CS-2399;UNC-569;UNC 569;UNC569, 10 mM in DMSO;1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine;1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-;N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine;anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl
CBNumber: CB72630103
Molecular Formula: C22H29FN6
Formula Weight: 396.5
MOL File: 1350547-65-7.mol

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UNC569 Property

storage temp.: Store at -20°C
solubility: DMF: 2.5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: 2 mg/ml
form: A crystalline solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22966
Product name: UNC569
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22966
Product name: UNC569
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 22966
Product name: UNC569
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 22966
Product name: UNC569
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

AK Scientific

Product number: 6662DK
Product name: 1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine
Packaging: 25mg
Price: $735
Updated: 2021/12/16

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UNC569 Chemical Properties,Usage,Production

Uses

UNC 569 induces morphological changes in pigment epithelia and photoreceptor cells in retina through MerTK inhibition in mice. A specific MerTK inhibitor.

in vivo

The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (V_ss of 5.83 L/kg), and good oral bioavailability (57%)^[1].
Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 μM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish^[2].

IC 50

Axl; Tyro3; Mer

UNC569 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC569 Suppliers

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1350547-65-7, UNC569Related Search:

UNC0321 UNC 1079 UNC 0224 UNC3866 UNC0379 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC0646 NUC-7738 UNC2025 UNC0638 UNC-0642 UNC 0631 UNC 1999

UNC569

1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-

CS-2399

UNC-569;UNC 569

anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl

1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine

UNC569, 10 mM in DMSO

1350547-65-7

C22H29FN6