UNC0321
- Product Name
- UNC0321
- CAS No.
- 1238673-32-9
- Chemical Name
- UNC0321
- Synonyms
- UNC0321;UNC0321(UNC-0321);UNC 0321; UNC-0321; UNC0321; UNC-0321;H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor;7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine;7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
- CBNumber
- CB92628498
- Molecular Formula
- C27H45N7O3
- Formula Weight
- 515.69
- MOL File
- 1238673-32-9.mol
UNC0321 Property
- Boiling point:
- 664.7±65.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 31 mg/mL (60.11 mM)
- pka
- 9.34±0.70(Predicted)
- form
- Powder
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 377024
- Product name
- UNC0321
- Packaging
- 50mg
- Price
- $1011
- Updated
- 2021/12/16
- Product number
- INB0001553
- Product name
- UNC-0321
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.8
- Updated
- 2021/12/16
- Product number
- CS-2211
- Product name
- UNC0321
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- CS-2211
- Product name
- UNC0321
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-2211
- Product name
- UNC0321
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $840
- Updated
- 2021/12/16
UNC0321 Chemical Properties,Usage,Production
Definition
ChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.
Biological Activity
UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.
in vitro
In G9a ECSD and CLOT assays, the IC 50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC 50 values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.
target
G9a 63 pM (Ki) | G9a 6-9 nM (IC 50 ) | GLP 15-23 nM (IC 50 ) |
UNC0321 Preparation Products And Raw materials
Raw materials
Preparation Products
UNC0321 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 56
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 18800159827
- youcochem@163.com
- Country
- China
- ProdList
- 161
- Advantage
- 50
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 0431-0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 3972
- Advantage
- 55