CPI-455

Product Name: CPI-455
CAS No.: 1628208-23-0
Chemical Name: CPI-455
Synonyms: CPI-455;CCPI-455;CPI-455, >98%;CPI 455;CPI455;CPI-455(free base);CPI 455;CPI-455;CPI455;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-
CBNumber: CB83129362
Molecular Formula: C16H14N4O
Formula Weight: 278.31
MOL File: 1628208-23-0.mol

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CPI-455 Property

Boiling point:: 488.7±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: solid
pka: -5.10±0.60(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22127
Product name: CPI-455
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 22127
Product name: CPI-455
Purity: ≥98%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 22127
Product name: CPI-455
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 22127
Product name: CPI-455
Purity: ≥98%
Packaging: 25mg
Price: $320
Updated: 2024/03/01

ChemScene

Product number: CS-6133
Product name: CPI-455
Purity: 98.95%
Packaging: 25mg
Price: $396
Updated: 2021/12/16

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CPI-455 Chemical Properties,Usage,Production

Description

CPI-455 (1628208-23-0) is a potent (IC50?= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1?CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells?in vitro.2?KDM5 demethylases have recently been shown to repress the immune response to tumors?via?suppression of STING.3

Uses

CPI-455 is a potent KDM5 demethylase inhibitor.

References

1) Vinogradova?et al.?(2016),?An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells;?Nat. Chem. Biol.?12?531 2) Leadem?et al.?(2018),?A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2’-Deoxycytidine;?Cancer Res.?78?1127 3) Wu?et al.?(2018),?KDM5 histone demethylases repress immune response via suppression of STING;?PLoS Biol.?16?e2006134dfd

CPI-455 Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-455 Suppliers

China 66 India 1 United States 11 Global 78

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Fax: +86-25-52131256
Email: 799750417@qq.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4456
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8014
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 6527
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 7539
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

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View Lastest Price from CPI-455 manufacturers

Career Henan Chemical Co

Product: CPI-455 1628208-23-0
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

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CPI 455;CPI455

CPI 455;CPI-455;CPI455

CPI-455, >98%

CPI-455(free base)

CPI-455

6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-

CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit

CCPI-455

1628208-23-0