CPI-455
- Product Name
- CPI-455
- CAS No.
- 1628208-23-0
- Chemical Name
- CPI-455
- Synonyms
- CPI-455;CCPI-455;CPI-455, >98%;CPI 455;CPI455;CPI-455(free base);CPI 455;CPI-455;CPI455;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-
- CBNumber
- CB83129362
- Molecular Formula
- C16H14N4O
- Formula Weight
- 278.31
- MOL File
- 1628208-23-0.mol
CPI-455 Property
- Boiling point:
- 488.7±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- form
- solid
- pka
- -5.10±0.60(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 22127
- Product name
- CPI-455
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 22127
- Product name
- CPI-455
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 22127
- Product name
- CPI-455
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 22127
- Product name
- CPI-455
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $320
- Updated
- 2024/03/01
- Product number
- CS-6133
- Product name
- CPI-455
- Purity
- 98.95%
- Packaging
- 25mg
- Price
- $396
- Updated
- 2021/12/16
CPI-455 Chemical Properties,Usage,Production
Description
CPI-455 (1628208-23-0) is a potent (IC50?= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1?CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells?in vitro.2?KDM5 demethylases have recently been shown to repress the immune response to tumors?via?suppression of STING.3
Uses
CPI-455 is a potent KDM5 demethylase inhibitor.
References
1) Vinogradova?et al.?(2016),?An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells;?Nat. Chem. Biol.?12?531 2) Leadem?et al.?(2018),?A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2’-Deoxycytidine;?Cancer Res.?78?1127 3) Wu?et al.?(2018),?KDM5 histone demethylases repress immune response via suppression of STING;?PLoS Biol.?16?e2006134dfd
CPI-455 Preparation Products And Raw materials
Raw materials
Preparation Products
CPI-455 Suppliers
View Lastest Price from CPI-455 manufacturers
- Product
- CPI-455 1628208-23-0
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05