ChemicalBook > CAS DataBase List > CPI-455

CPI-455

Product Name
CPI-455
CAS No.
1628208-23-0
Chemical Name
CPI-455
Synonyms
CPI-455;CCPI-455;CPI-455, >98%;CPI 455;CPI455;CPI-455(free base);CPI 455;CPI-455;CPI455;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-
CBNumber
CB83129362
Molecular Formula
C16H14N4O
Formula Weight
278.31
MOL File
1628208-23-0.mol
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CPI-455 Property

Boiling point:
488.7±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
form 
solid
pka
-5.10±0.60(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22127
Product name
CPI-455
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
22127
Product name
CPI-455
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
22127
Product name
CPI-455
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
22127
Product name
CPI-455
Purity
≥98%
Packaging
25mg
Price
$320
Updated
2024/03/01
ChemScene
Product number
CS-6133
Product name
CPI-455
Purity
98.95%
Packaging
25mg
Price
$396
Updated
2021/12/16
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CPI-455 Chemical Properties,Usage,Production

Description

CPI-455 (1628208-23-0) is a potent (IC50?= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1?CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells?in vitro.2?KDM5 demethylases have recently been shown to repress the immune response to tumors?via?suppression of STING.3

Uses

CPI-455 is a potent KDM5 demethylase inhibitor.

References

1) Vinogradova?et al.?(2016),?An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells;?Nat. Chem. Biol.?12?531 2) Leadem?et al.?(2018),?A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2’-Deoxycytidine;?Cancer Res.?78?1127 3) Wu?et al.?(2018),?KDM5 histone demethylases repress immune response via suppression of STING;?PLoS Biol.?16?e2006134dfd

CPI-455 Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-455 Suppliers

China 66 India 1 United States 11 Global 78
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from CPI-455 manufacturers

Career Henan Chemical Co
Product
CPI-455 1628208-23-0
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

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  • CPI 455;CPI455
  • CPI 455;CPI-455;CPI455
  • CPI-455, >98%
  • CPI-455(free base)
  • CPI-455
  • 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-
  • CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit
  • CCPI-455
  • 1628208-23-0