HA-15

Product Name: HA-15
CAS No.: 1609402-14-3
Chemical Name: HA-15
Synonyms: HA-15;CS-2893;HA15;HA 15;HA15 >=98% (HPLC);HA15, 10 mM in DMSO;HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins;N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide;Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
CBNumber: CB93145837
Molecular Formula: C23H22N4O3S2
Formula Weight: 466.58
MOL File: 1609402-14-3.mol

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HA-15 Property

Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:71.5(Max Conc. mg/mL);153.24(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);96.45(Max Conc. mM)
form: A solid
pka: 7.32±0.50(Predicted)
color: Light yellow to green yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $436
Updated: 2025/07/31

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

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HA-15 Chemical Properties,Usage,Production

Definition

ChEBI: HA15 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells. It has a role as an antineoplastic agent. It is a sulfonamide, a member of 1,3-thiazoles, a member of acetamides, a tertiary amino compound, an aminonaphthalene and a biaryl.

Biological Activity

HA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). Antitumor activity in melanoma cells tested, including cells isolated from patients and cells resistant to BRAF inhibitors.

in vitro

HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; in melanoma cells, it overcomes its resistance to BRAF inhibitors.

in vivo

In xenograft mouse models (bearing melanoma cells sensitive or resistant to BRAF inhibitors), HA15 was able to induce endoplasmic reticulum stress leading to cancer cell death.

target

Target	Value
BiP/GRP78/HSPA5 ()

HA-15 Preparation Products And Raw materials

Raw materials

Preparation Products

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HA-15 Suppliers

China 78 India 1 United States 7 Global 86

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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Advantage: 64

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
Country: China
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Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

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Email: sales@zehanbiopharma.com
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ELSA BIOTECHNOLOGY CO.,LTD.

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Fax: 86-025-84106591
Email: sales@elsa-biotech.com
Country: China
ProdList: 99
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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1609402-14-3, HA-15Related Search:

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HA-15

CS-2893

HA15;HA 15

Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-

HA15 >=98% (HPLC)

N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide

HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins

HA15, 10 mM in DMSO

1609402-14-3