HA-15

ChemicalBook > CAS DataBase List > HA-15

Product Name: HA-15
CAS No.: 1609402-14-3
Chemical Name: HA-15
Synonyms: HA-15;CS-2893;HA15;HA 15;HA15 >=98% (HPLC);HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins;N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide;Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
CBNumber: CB93145837
Molecular Formula: C23H22N4O3S2
Formula Weight: 466.58
MOL File: 1609402-14-3.mol

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HA-15 Property

Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:71.5(Max Conc. mg/mL);153.24(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);96.45(Max Conc. mM)
form: A solid
pka: 7.32±0.50(Predicted)
color: Light yellow to green yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $102
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $413
Updated: 2023/06/20

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

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HA-15 Chemical Properties,Usage,Production

Definition

ChEBI: HA15 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells. It has a role as an antineoplastic agent. It is a sulfonamide, a member of 1,3-thiazoles, a member of acetamides, a tertiary amino compound, an aminonaphthalene and a biaryl.

Biological Activity

HA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). Antitumor activity in melanoma cells tested, including cells isolated from patients and cells resistant to BRAF inhibitors.

in vitro

HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; in melanoma cells, it overcomes its resistance to BRAF inhibitors.

in vivo

In xenograft mouse models (bearing melanoma cells sensitive or resistant to BRAF inhibitors), HA15 was able to induce endoplasmic reticulum stress leading to cancer cell death.

target

Target	Value
BiP/GRP78/HSPA5 ()

HA-15 Preparation Products And Raw materials

Raw materials

Preparation Products

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1609402-14-3, HA-15Related Search:

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HA-15

CS-2893

HA15;HA 15

Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-

HA15 >=98% (HPLC)

N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide

HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins

1609402-14-3