HA-15

ChemicalBook > CAS DataBase List > HA-15

Product Name: HA-15
CAS No.: 1609402-14-3
Chemical Name: HA-15
Synonyms: HA-15;CS-2893;HA15;HA 15;HA15 >=98% (HPLC);HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins;N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide;Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
CBNumber: CB93145837
Molecular Formula: C23H22N4O3S2
Formula Weight: 466.58
MOL File: 1609402-14-3.mol

Less

HA-15 Property

Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:71.5(Max Conc. mg/mL);153.24(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);96.45(Max Conc. mM)
form: A solid
pka: 7.32±0.50(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $102
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML2118
Product name: HA15
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $413
Updated: 2023/06/20

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-5825
Product name: HA15
Purity: 99.84%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

Less

HA-15 Chemical Properties,Usage,Production

Definition

ChEBI: HA15 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells. It has a role as an antineoplastic agent. It is a sulfonamide, a member of 1,3-thiazoles, a member of acetamides, a tertiary amino compound, an aminonaphthalene and a biaryl.

Biological Activity

HA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). Antitumor activity in melanoma cells tested, including cells isolated from patients and cells resistant to BRAF inhibitors.

in vitro

HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; in melanoma cells, it overcomes its resistance to BRAF inhibitors.

in vivo

In xenograft mouse models (bearing melanoma cells sensitive or resistant to BRAF inhibitors), HA15 was able to induce endoplasmic reticulum stress leading to cancer cell death.

target

Target	Value
BiP/GRP78/HSPA5 ()

HA-15 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

HA-15 Suppliers

China 63 India 1 United States 6 Global 70

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4182
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 990
Advantage: 55

ELSA BIOTECHNOLOGY CO.,LTD.

Tel: 15261860116
Fax: 86-025-84106591
Email: sales@elsa-biotech.com
Country: China
ProdList: 99
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9779
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29796
Advantage: 68

Shanghai BetterBioChem Co., Ltd.

Tel: +86-18017644823
Fax: - QQ：1910610264
Email: sales@betterbiochem.com
Country: China
ProdList: 325
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3245
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1991
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3574
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1971
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9771
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 10006
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44843
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4495
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Fax: 18003835034（微信）
Email: 2853979819@qq.com
Country: China
ProdList: 8780
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2635
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 63720
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6749
Advantage: 58

Wuhan Shanhai Zhihe Biotechnology Co., Ltd.

Tel: 17771424646
Email: shoubull@126.com
Country: China
ProdList: 966
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9892
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24018
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5278
Advantage: 58

Jinan Sanbao Biotechnology Co., Ltd.

Tel: 13854185395; 13854185395
Email: sanbaobiotech@126.com
Country: China
ProdList: 9510
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29989
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2942
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5019
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48467
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-18670069958 18670069958
Email: 184792226@qq.com
Country: China
ProdList: 3060
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32686
Advantage: 60

Wuhan Jingkang en Biomedical Technology Co., Ltd

Tel: +8613720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 4664
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43348
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 11681
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6652
Advantage: 58

Hongtuo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@ontorespeptide.com
Country: CHINA
ProdList: 697
Advantage: 58

1609402-14-3, HA-15Related Search:

UNC0321 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015 GDC-0879 4-iodo-3-nitrobenzamide VBY-825

HA-15

CS-2893

HA15;HA 15

Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-

HA15 >=98% (HPLC)

N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide

HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins

1609402-14-3