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UNC0321

Product Name
UNC0321
CAS No.
1238673-32-9
Chemical Name
UNC0321
Synonyms
UNC0321;UNC0321(UNC-0321);UNC 0321; UNC-0321; UNC0321; UNC-0321;H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor;7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine;7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
CBNumber
CB92628498
Molecular Formula
C27H45N7O3
Formula Weight
515.69
MOL File
1238673-32-9.mol
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UNC0321 Property

Boiling point:
664.7±65.0 °C(Predicted)
Density 
1.150±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 31 mg/mL (60.11 mM)
pka
9.34±0.70(Predicted)
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological
Product number
377024
Product name
UNC0321
Packaging
50mg
Price
$1011
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001553
Product name
UNC-0321
Purity
95.00%
Packaging
5MG
Price
$505.8
Updated
2021/12/16
ChemScene
Product number
CS-2211
Product name
UNC0321
Purity
>98.0%
Packaging
5mg
Price
$116
Updated
2021/12/16
ChemScene
Product number
CS-2211
Product name
UNC0321
Purity
>98.0%
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-2211
Product name
UNC0321
Purity
>98.0%
Packaging
50mg
Price
$840
Updated
2021/12/16
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UNC0321 Chemical Properties,Usage,Production

Definition

ChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.

Biological Activity

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

in vitro

In G9a ECSD and CLOT assays, the IC 50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC 50 values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.

target

G9a

63 pM (Ki)

G9a

6-9 nM (IC 50 )

GLP

15-23 nM (IC 50 )

UNC0321 Preparation Products And Raw materials

Raw materials

Preparation Products

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1238673-32-9, UNC0321Related Search:

UNC 1999 UNC0379 UNC569 UNC0638 UNC 0224 UNC-0642 UNC 0631 HA-15 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015

  • UNC0321
  • 7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine
  • 7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
  • UNC0321(UNC-0321)
  • UNC 0321; UNC-0321; UNC0321; UNC-0321
  • 4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
  • H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor
  • 1238673-32-9
  • C27H45N7O3